High Levels of Virus-Specific CD4^sup +^ T Cells Predict Severe Pandemic Influenza A Virus Infection

• Published in: American journal of respiratory and critical care medicine Vol. 186; no. 12; p. 1292
• Main Authors: Zhao, Yan, Zhang, Yong-Hong, Denney, Laura, Young, Duncan, Powell, Tim J, Peng, Yan-Chun, Li, Ning, Yan, Hui-Ping, Wang, Da-Yan, Shu, Yue-Long, Kendrick, Yvonne, McMichael, Andrew J, Ho, Ling-Pei, Dong, Tao
• Format: Journal Article
• Language: English
• Published: New York American Thoracic Society 15.12.2012
• Subjects: Antigens; Cells; Cytokines; Dengue fever; Disease; Infections; Intensive care; Lungs; Lymphocytes; Pandemics; Patients; Peptides; Swine flu; United Kingdom > UK

T-cell responses have been implicated in control and exacerbation of lung injury during influenza A virus (IAV) infection. To examine the breadth and magnitude of influenza-specific CD4(+) and CD8(+) T-cell responses during acute phase of infection. Influenza-specific T-cell response to the entire p...