Pancreatic cancer genomes reveal aberrations inaxonguidance pathway genes

• Published in: Nature (London) Vol. 491; no. 7424; p. 399
• Main Authors: Biankin, Andrew V, Waddell, Nicola, Kassahn, Karin S, Gingras, Marie-Claude, Muthuswamy, Lakshmi B, Johns, Amber L, Miller, David K, Wilson, Peter J, Patch, Ann-Marie, Wu, Jianmin, Capelli, Paola, Corbo, Vincenzo, Scardoni, Maria, Tempero, Margaret A, Mann, Karen M, Perez-Mancera, Pedro A, Chang, David K, Adams, David J, Largaespada, David A, Wessels, Lodewyk F A, Rust, Alistair G, Stein, Lincoln D, Musgrove, Elizabeth A, Eshleman, James R, Sutherland, Robert L, Wheeler, David A, McPherson, John D, Gibbs, Richard A, Grimmond, Sean M, Song, Sarah, Harliwong, Ivon, Idrisoglu, Senel, Nourse, Craig, Nourbakhsh, Ehsan, Manning, Suzanne, Wani, Shivangi, Gongora, Milena, Pajic, Marina, Gill, Anthony J, Anderson, Matthew, Holmes, Oliver, Leonard, Conrad, Wood, Scott, Xu, Qinying, Nones, Katia, Fink, J Lynn, Christ, Angelika, Bruxner, Tim, Cloonan, Nicole, Kolle, Gabriel, Newell, Felicity, Pinese, Mark, Humphris, Jeremy L, Kaplan, Warren, Jones, Marc D, Humphrey, Emily S, Chou, Angela, Chin, Venessa T, Chantrill, Lorraine A, Mawson, Amanda, Samra, Jaswinder S, Kench, James G, Lovell, Jessica A, Daly, Roger J, Merrett, Neil D, Epari, Krishna, Nguyen, Nam Q, Barbour, Andrew, Zeps, Nikolajs, Kakkar, Nipun, Wang, Min, Muzny, Donna M, Brunicardi, F Charles, Reid, Jeffrey G, Drummond, Jennifer, Chang, Kyle, Dinh, Huyen, Buhay, Christian J, Beck, Timothy, Timms, Lee, Sam, Michelle, Begley, Kimberly, Brown, Andrew, Pai, Deepa, Panchal, Ami, Buchner, Nicholas, De Borja, Richard, Denroche, Robert E, Yung, Christina K, Serra, Stefano, Onetto, Nicole, Mukhopadhyay, Debabrata, Tsao, Ming-Sound, Shaw, Patricia A, Petersen, Gloria M, Gallinger, Steven, Hruban, Ralph H, Maitra, Anirban, Iacobuzio-Donahue, Christine A, Wolfgang, Christopher L
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group 15.11.2012
• Subjects: Animal models; Carcinogenesis; Genes; Heterogeneity; Medical research; Mutation; Pancreas; Pancreatic cancer

Pancreatic cancer is a highly lethal malignancy with few effective therapies. We performed exome sequencing and copy number analysis to define genomic aberrations in a prospectively accrued clinical cohort (n = 142) of early (stage I and II) sporadic pancreatic ductal adenocarcinoma. Detailed analys...