Pancreatic cancer genomes reveal aberrations inaxonguidance pathway genes
Pancreatic cancer is a highly lethal malignancy with few effective therapies. We performed exome sequencing and copy number analysis to define genomic aberrations in a prospectively accrued clinical cohort (n = 142) of early (stage I and II) sporadic pancreatic ductal adenocarcinoma. Detailed analys...
Saved in:
Published in | Nature (London) Vol. 491; no. 7424; p. 399 |
---|---|
Main Authors | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
Format | Journal Article |
Language | English |
Published |
London
Nature Publishing Group
15.11.2012
|
Subjects | |
Online Access | Get full text |
Cover
Loading…
Abstract | Pancreatic cancer is a highly lethal malignancy with few effective therapies. We performed exome sequencing and copy number analysis to define genomic aberrations in a prospectively accrued clinical cohort (n = 142) of early (stage I and II) sporadic pancreatic ductal adenocarcinoma. Detailed analysis of 99 informative tumours identified substantial heterogeneity with 2,016 non-silent mutations and 1,628 copy-number variations. We define 16 significantly mutated genes, reaffirming known mutations (KRAS, TP53, CDKN2A, SMAD4, MLL3, TGFBR2, ARID1A and SF3B1), and uncover novel mutated genes including additional genes involved in chromatin modification (EPC1 and ARID2), DNA damage repair (ATM) and other mechanisms (ZIM2, MAP2K4, NALCN, SLC16A4 and MAGEA6). Integrative analysis with in vitro functional data and animal models provided supportive evidence for potential roles for these genetic aberrations in carcinogenesis. Pathway-based analysis of recurrently mutated genes recapitulated clustering in core signalling pathways in pancreatic ductal adenocarcinoma, and identified new mutated genes in each pathway. We also identified frequent and diverse somatic aberrations in genes described traditionally as embryonic regulators of axon guidance, particularly SLIT/ROBO signalling, which was also evident in murine Sleeping Beauty transposon-mediated somatic mutagenesis models of pancreatic cancer, providing further supportive evidence for the potential involvement of axon guidance genes in pancreatic carcinogenesis. [PUBLICATION ABSTRACT] |
---|---|
AbstractList | Pancreatic cancer is a highly lethal malignancy with few effective therapies. We performed exome sequencing and copy number analysis to define genomic aberrations in a prospectively accrued clinical cohort (n = 142) of early (stage I and II) sporadic pancreatic ductal adenocarcinoma. Detailed analysis of 99 informative tumours identified substantial heterogeneity with 2,016 non-silent mutations and 1,628 copy-number variations. We define 16 significantly mutated genes, reaffirming known mutations (KRAS, TP53, CDKN2A, SMAD4, MLL3, TGFBR2, ARID1A and SF3B1), and uncover novel mutated genes including additional genes involved in chromatin modification (EPC1 and ARID2), DNA damage repair (ATM) and other mechanisms (ZIM2, MAP2K4, NALCN, SLC16A4 and MAGEA6). Integrative analysis with in vitro functional data and animal models provided supportive evidence for potential roles for these genetic aberrations in carcinogenesis. Pathway-based analysis of recurrently mutated genes recapitulated clustering in core signalling pathways in pancreatic ductal adenocarcinoma, and identified new mutated genes in each pathway. We also identified frequent and diverse somatic aberrations in genes described traditionally as embryonic regulators of axon guidance, particularly SLIT/ROBO signalling, which was also evident in murine Sleeping Beauty transposon-mediated somatic mutagenesis models of pancreatic cancer, providing further supportive evidence for the potential involvement of axon guidance genes in pancreatic carcinogenesis. [PUBLICATION ABSTRACT] |
Author | Leonard, Conrad Christ, Angelika Kolle, Gabriel Adams, David J Chou, Angela De Borja, Richard Stein, Lincoln D Tsao, Ming-Sound Hudson, Thomas J Grimmond, Sean M Pinese, Mark Jones, Marc D Muthuswamy, Lakshmi B Biankin, Andrew V Samra, Jaswinder S Nourbakhsh, Ehsan Brunicardi, F Charles Buhay, Christian J Brown, Andrew Sam, Michelle Pinho, Andreia V Merrett, Neil D Toon, Christopher Capelli, Paola Denroche, Robert E Reid, Jeffrey G McPherson, John D Wang, Min Pearson, John V Wani, Shivangi Pai, Deepa Buchner, Nicholas Bruxner, Tim Iacobuzio-Donahue, Christine A Lovell, Jessica A Lewis, Lora R Colvin, Emily K Timms, Lee Scarpa, Aldo Pajic, Marina Yung, Christina K Wu, Yuan Qing Wheeler, David A Gardiner, Brooke B Gallinger, Steven Nguyen, Nam Q Beck, Timothy Largaespada, David A Chang, David K Tortora, Giampaolo Harliwong, Ivon Mukhopadhyay, Debabrata Hruban, Ralph H Scardoni, Maria Onetto, Nicole Humphris, Jeremy L Kaplan, Warren Newell, Felicity Jenkins, Nancy A Fisher, William E Copeland, Neal G Taylor, Darrin Patch, Ann-Marie Lawlor, Rita T Wood |
Author_xml | – sequence: 1 givenname: Andrew surname: Biankin middlename: V fullname: Biankin, Andrew V – sequence: 2 givenname: Nicola surname: Waddell fullname: Waddell, Nicola – sequence: 3 givenname: Karin surname: Kassahn middlename: S fullname: Kassahn, Karin S – sequence: 4 givenname: Marie-Claude surname: Gingras fullname: Gingras, Marie-Claude – sequence: 5 givenname: Lakshmi surname: Muthuswamy middlename: B fullname: Muthuswamy, Lakshmi B – sequence: 6 givenname: Amber surname: Johns middlename: L fullname: Johns, Amber L – sequence: 7 givenname: David surname: Miller middlename: K fullname: Miller, David K – sequence: 8 givenname: Peter surname: Wilson middlename: J fullname: Wilson, Peter J – sequence: 9 givenname: Ann-Marie surname: Patch fullname: Patch, Ann-Marie – sequence: 10 givenname: Jianmin surname: Wu fullname: Wu, Jianmin – sequence: 13 givenname: Paola surname: Capelli fullname: Capelli, Paola – sequence: 14 givenname: Vincenzo surname: Corbo fullname: Corbo, Vincenzo – sequence: 15 givenname: Maria surname: Scardoni fullname: Scardoni, Maria – sequence: 17 givenname: Margaret surname: Tempero middlename: A fullname: Tempero, Margaret A – sequence: 18 givenname: Karen surname: Mann middlename: M fullname: Mann, Karen M – sequence: 20 givenname: Pedro surname: Perez-Mancera middlename: A fullname: Perez-Mancera, Pedro A – sequence: 21 givenname: David surname: Chang middlename: K fullname: Chang, David K – sequence: 22 givenname: David surname: Adams middlename: J fullname: Adams, David J – sequence: 23 givenname: David surname: Largaespada middlename: A fullname: Largaespada, David A – sequence: 24 givenname: Lodewyk surname: Wessels middlename: F A fullname: Wessels, Lodewyk F A – sequence: 25 givenname: Alistair surname: Rust middlename: G fullname: Rust, Alistair G – sequence: 26 givenname: Lincoln surname: Stein middlename: D fullname: Stein, Lincoln D – sequence: 29 givenname: Elizabeth surname: Musgrove middlename: A fullname: Musgrove, Elizabeth A – sequence: 31 givenname: James surname: Eshleman middlename: R fullname: Eshleman, James R – sequence: 34 givenname: Robert surname: Sutherland middlename: L fullname: Sutherland, Robert L – sequence: 35 givenname: David surname: Wheeler middlename: A fullname: Wheeler, David A – sequence: 37 givenname: John surname: McPherson middlename: D fullname: McPherson, John D – sequence: 38 givenname: Richard surname: Gibbs middlename: A fullname: Gibbs, Richard A – sequence: 39 givenname: Sean surname: Grimmond middlename: M fullname: Grimmond, Sean M – sequence: 41 givenname: Sarah surname: Song fullname: Song, Sarah – sequence: 42 givenname: Ivon surname: Harliwong fullname: Harliwong, Ivon – sequence: 43 givenname: Senel surname: Idrisoglu fullname: Idrisoglu, Senel – sequence: 44 givenname: Craig surname: Nourse fullname: Nourse, Craig – sequence: 45 givenname: Ehsan surname: Nourbakhsh fullname: Nourbakhsh, Ehsan – sequence: 46 givenname: Suzanne surname: Manning fullname: Manning, Suzanne – sequence: 47 givenname: Shivangi surname: Wani fullname: Wani, Shivangi – sequence: 48 givenname: Milena surname: Gongora fullname: Gongora, Milena – sequence: 49 givenname: Marina surname: Pajic fullname: Pajic, Marina – sequence: 51 givenname: Anthony surname: Gill middlename: J fullname: Gill, Anthony J – sequence: 54 givenname: Matthew surname: Anderson fullname: Anderson, Matthew – sequence: 55 givenname: Oliver surname: Holmes fullname: Holmes, Oliver – sequence: 56 givenname: Conrad surname: Leonard fullname: Leonard, Conrad – sequence: 58 givenname: Scott surname: Wood fullname: Wood, Scott – sequence: 59 givenname: Qinying surname: Xu fullname: Xu, Qinying – sequence: 60 givenname: Katia surname: Nones fullname: Nones, Katia – sequence: 61 givenname: J surname: Fink middlename: Lynn fullname: Fink, J Lynn – sequence: 62 givenname: Angelika surname: Christ fullname: Christ, Angelika – sequence: 63 givenname: Tim surname: Bruxner fullname: Bruxner, Tim – sequence: 64 givenname: Nicole surname: Cloonan fullname: Cloonan, Nicole – sequence: 65 givenname: Gabriel surname: Kolle fullname: Kolle, Gabriel – sequence: 66 givenname: Felicity surname: Newell fullname: Newell, Felicity – sequence: 67 givenname: Mark surname: Pinese fullname: Pinese, Mark – sequence: 69 givenname: Jeremy surname: Humphris middlename: L fullname: Humphris, Jeremy L – sequence: 70 givenname: Warren surname: Kaplan fullname: Kaplan, Warren – sequence: 71 givenname: Marc surname: Jones middlename: D fullname: Jones, Marc D – sequence: 74 givenname: Emily surname: Humphrey middlename: S fullname: Humphrey, Emily S – sequence: 75 givenname: Angela surname: Chou fullname: Chou, Angela – sequence: 76 givenname: Venessa surname: Chin middlename: T fullname: Chin, Venessa T – sequence: 77 givenname: Lorraine surname: Chantrill middlename: A fullname: Chantrill, Lorraine A – sequence: 78 givenname: Amanda surname: Mawson fullname: Mawson, Amanda – sequence: 79 givenname: Jaswinder surname: Samra middlename: S fullname: Samra, Jaswinder S – sequence: 80 givenname: James surname: Kench middlename: G fullname: Kench, James G – sequence: 81 givenname: Jessica surname: Lovell middlename: A fullname: Lovell, Jessica A – sequence: 82 givenname: Roger surname: Daly middlename: J fullname: Daly, Roger J – sequence: 83 givenname: Neil surname: Merrett middlename: D fullname: Merrett, Neil D – sequence: 85 givenname: Krishna surname: Epari fullname: Epari, Krishna – sequence: 86 givenname: Nam surname: Nguyen middlename: Q fullname: Nguyen, Nam Q – sequence: 87 givenname: Andrew surname: Barbour fullname: Barbour, Andrew – sequence: 88 givenname: Nikolajs surname: Zeps fullname: Zeps, Nikolajs – sequence: 89 givenname: Nipun surname: Kakkar fullname: Kakkar, Nipun – sequence: 92 givenname: Min surname: Wang fullname: Wang, Min – sequence: 93 givenname: Donna surname: Muzny middlename: M fullname: Muzny, Donna M – sequence: 95 givenname: F surname: Brunicardi middlename: Charles fullname: Brunicardi, F Charles – sequence: 97 givenname: Jeffrey surname: Reid middlename: G fullname: Reid, Jeffrey G – sequence: 98 givenname: Jennifer surname: Drummond fullname: Drummond, Jennifer – sequence: 99 givenname: Kyle surname: Chang fullname: Chang, Kyle – sequence: 102 givenname: Huyen surname: Dinh fullname: Dinh, Huyen – sequence: 103 givenname: Christian surname: Buhay middlename: J fullname: Buhay, Christian J – sequence: 104 givenname: Timothy surname: Beck fullname: Beck, Timothy – sequence: 105 givenname: Lee surname: Timms fullname: Timms, Lee – sequence: 106 givenname: Michelle surname: Sam fullname: Sam, Michelle – sequence: 107 givenname: Kimberly surname: Begley fullname: Begley, Kimberly – sequence: 108 givenname: Andrew surname: Brown fullname: Brown, Andrew – sequence: 109 givenname: Deepa surname: Pai fullname: Pai, Deepa – sequence: 110 givenname: Ami surname: Panchal fullname: Panchal, Ami – sequence: 111 givenname: Nicholas surname: Buchner fullname: Buchner, Nicholas – sequence: 112 givenname: Richard surname: De Borja fullname: De Borja, Richard – sequence: 113 givenname: Robert surname: Denroche middlename: E fullname: Denroche, Robert E – sequence: 114 givenname: Christina surname: Yung middlename: K fullname: Yung, Christina K – sequence: 115 givenname: Stefano surname: Serra fullname: Serra, Stefano – sequence: 116 givenname: Nicole surname: Onetto fullname: Onetto, Nicole – sequence: 117 givenname: Debabrata surname: Mukhopadhyay fullname: Mukhopadhyay, Debabrata – sequence: 118 givenname: Ming-Sound surname: Tsao fullname: Tsao, Ming-Sound – sequence: 119 givenname: Patricia surname: Shaw middlename: A fullname: Shaw, Patricia A – sequence: 120 givenname: Gloria surname: Petersen middlename: M fullname: Petersen, Gloria M – sequence: 121 givenname: Steven surname: Gallinger fullname: Gallinger, Steven – sequence: 122 givenname: Ralph surname: Hruban middlename: H fullname: Hruban, Ralph H – sequence: 123 givenname: Anirban surname: Maitra fullname: Maitra, Anirban – sequence: 124 givenname: Christine surname: Iacobuzio-Donahue middlename: A fullname: Iacobuzio-Donahue, Christine A – sequence: 126 givenname: Christopher surname: Wolfgang middlename: L fullname: Wolfgang, Christopher L |
BookMark | eNqNi8sOgjAQRRujiaD-QxPXJC1UWtdGozsX7smII0Jwii34-Hsh8QNc3ZOcc0M2Jks4YoFUOo1UavSYBULEJhImSacs9L4SQqykVgE7HIFyh9CWOc97RMcLJHtHzx0-EWoOZ3Su95Y8LwneloquvAwpb6C9veAzPNDP2eQKtcfFb2dsudueNvuocfbRoW-zynaOepXJOE7U2hipk_-qL14yQFc |
CODEN | NATUAS |
ContentType | Journal Article |
Copyright | Copyright Nature Publishing Group Nov 15, 2012 |
Copyright_xml | – notice: Copyright Nature Publishing Group Nov 15, 2012 |
DBID | 3V. 7QG 7QL 7QP 7QR 7RV 7SN 7SS 7ST 7T5 7TG 7TK 7TM 7TO 7U9 7X2 7X7 7XB 88A 88E 88G 88I 8AF 8AO 8C1 8FD 8FE 8FG 8FH 8FI 8FJ 8FK 8G5 ABJCF ABUWG AFKRA ARAPS ATCPS AZQEC BBNVY BEC BENPR BGLVJ BHPHI BKSAR C1K CCPQU D1I DWQXO FR3 FYUFA GHDGH GNUQQ GUQSH H94 HCIFZ K9. KB. KB0 KL. L6V LK8 M0K M0S M1P M2M M2O M2P M7N M7P M7S MBDVC NAPCQ P5Z P62 P64 PATMY PCBAR PDBOC PQEST PQQKQ PQUKI PSYQQ PTHSS PYCSY Q9U R05 RC3 S0X SOI |
DatabaseName | ProQuest Central (Corporate) Animal Behavior Abstracts Bacteriology Abstracts (Microbiology B) Calcium & Calcified Tissue Abstracts Chemoreception Abstracts Nursing & Allied Health Database Ecology Abstracts Entomology Abstracts (Full archive) Environment Abstracts Immunology Abstracts Meteorological & Geoastrophysical Abstracts Neurosciences Abstracts Nucleic Acids Abstracts Oncogenes and Growth Factors Abstracts Virology and AIDS Abstracts Agricultural Science Collection Health & Medical Collection ProQuest Central (purchase pre-March 2016) Biology Database (Alumni Edition) Medical Database (Alumni Edition) Psychology Database (Alumni) Science Database (Alumni Edition) STEM Database ProQuest Pharma Collection Public Health Database Technology Research Database ProQuest SciTech Collection ProQuest Technology Collection ProQuest Natural Science Collection Hospital Premium Collection Hospital Premium Collection (Alumni Edition) ProQuest Central (Alumni) (purchase pre-March 2016) Research Library (Alumni Edition) Materials Science & Engineering Collection ProQuest Central (Alumni) ProQuest Central Advanced Technologies & Aerospace Collection Agricultural & Environmental Science Collection ProQuest Central Essentials Biological Science Collection eLibrary ProQuest Central Technology Collection Natural Science Collection Earth, Atmospheric & Aquatic Science Collection Environmental Sciences and Pollution Management ProQuest One Community College ProQuest Materials Science Collection ProQuest Central Korea Engineering Research Database Health Research Premium Collection Health Research Premium Collection (Alumni) ProQuest Central Student Research Library Prep AIDS and Cancer Research Abstracts SciTech Premium Collection ProQuest Health & Medical Complete (Alumni) Materials Science Database Nursing & Allied Health Database (Alumni Edition) Meteorological & Geoastrophysical Abstracts - Academic ProQuest Engineering Collection Biological Sciences Agriculture Science Database Health & Medical Collection (Alumni Edition) Medical Database Psychology Database Research Library Science Database Algology Mycology and Protozoology Abstracts (Microbiology C) Biological Science Database Engineering Database Research Library (Corporate) Nursing & Allied Health Premium Advanced Technologies & Aerospace Database ProQuest Advanced Technologies & Aerospace Collection Biotechnology and BioEngineering Abstracts Environmental Science Database Earth, Atmospheric & Aquatic Science Database Materials Science Collection ProQuest One Academic Eastern Edition (DO NOT USE) ProQuest One Academic ProQuest One Academic UKI Edition ProQuest One Psychology Engineering Collection Environmental Science Collection ProQuest Central Basic University of Michigan Genetics Abstracts SIRS Editorial Environment Abstracts |
DatabaseTitle | Agricultural Science Database ProQuest One Psychology Research Library Prep ProQuest Central Student Oncogenes and Growth Factors Abstracts ProQuest Advanced Technologies & Aerospace Collection ProQuest Central Essentials Nucleic Acids Abstracts elibrary ProQuest AP Science SciTech Premium Collection Environmental Sciences and Pollution Management Health Research Premium Collection Meteorological & Geoastrophysical Abstracts Natural Science Collection Biological Science Collection Chemoreception Abstracts ProQuest Medical Library (Alumni) Engineering Collection Advanced Technologies & Aerospace Collection Engineering Database Virology and AIDS Abstracts ProQuest Science Journals (Alumni Edition) ProQuest Biological Science Collection ProQuest One Academic Eastern Edition Earth, Atmospheric & Aquatic Science Database Agricultural Science Collection ProQuest Hospital Collection ProQuest Technology Collection Health Research Premium Collection (Alumni) Biological Science Database Ecology Abstracts Neurosciences Abstracts ProQuest Hospital Collection (Alumni) Biotechnology and BioEngineering Abstracts Environmental Science Collection Entomology Abstracts Nursing & Allied Health Premium ProQuest Health & Medical Complete ProQuest One Academic UKI Edition Environmental Science Database ProQuest Nursing & Allied Health Source (Alumni) Engineering Research Database ProQuest One Academic Calcium & Calcified Tissue Abstracts Meteorological & Geoastrophysical Abstracts - Academic University of Michigan Technology Collection Technology Research Database SIRS Editorial Materials Science Collection ProQuest Health & Medical Complete (Alumni) ProQuest Central (Alumni Edition) ProQuest One Community College Research Library (Alumni Edition) ProQuest Natural Science Collection ProQuest Pharma Collection ProQuest Biology Journals (Alumni Edition) ProQuest Central Earth, Atmospheric & Aquatic Science Collection Genetics Abstracts ProQuest Engineering Collection Health and Medicine Complete (Alumni Edition) ProQuest Central Korea Bacteriology Abstracts (Microbiology B) Algology Mycology and Protozoology Abstracts (Microbiology C) Agricultural & Environmental Science Collection AIDS and Cancer Research Abstracts Materials Science Database ProQuest Research Library ProQuest Materials Science Collection ProQuest Public Health ProQuest Central Basic ProQuest Science Journals ProQuest Nursing & Allied Health Source ProQuest Psychology Journals (Alumni) ProQuest SciTech Collection Advanced Technologies & Aerospace Database ProQuest Medical Library ProQuest Psychology Journals Animal Behavior Abstracts Materials Science & Engineering Collection Immunology Abstracts Environment Abstracts ProQuest Central (Alumni) |
DatabaseTitleList | Agricultural Science Database |
Database_xml | – sequence: 1 dbid: 8FG name: ProQuest Technology Collection url: https://search.proquest.com/technologycollection1 sourceTypes: Aggregation Database |
DeliveryMethod | fulltext_linktorsrc |
Discipline | Sciences (General) Physics |
EISSN | 1476-4687 |
ExternalDocumentID | 2834366461 |
GroupedDBID | --- --Z -DZ -ET -~X .55 .CO .HR .XZ 00M 07C 08P 0R~ 0WA 123 186 1OL 1VR 29M 2KS 2XV 39C 3V. 4.4 41X 53G 5RE 6TJ 70F 7QG 7QL 7QP 7QR 7RV 7SN 7SS 7ST 7T5 7TG 7TK 7TM 7TO 7U9 7X2 7X7 7XB 7XC 85S 88A 88E 88I 8AF 8AO 8C1 8CJ 8FD 8FE 8FG 8FH 8FI 8FJ 8FK 8G5 8R4 8R5 8WZ 97F 97L A6W A7Z A8Z AAEEF AAHBH AAHTB AAIKC AAKAB AAKAS AAMNW AASDW AAYEP AAYZH AAZLF ABAWZ ABDBF ABFSI ABIVO ABJCF ABJNI ABLJU ABOCM ABPEJ ABPPZ ABUWG ABWJO ABZEH ACBEA ACBWK ACGFO ACGFS ACGOD ACIWK ACKOT ACMJI ACNCT ACPRK ACWUS ADBBV ADFRT ADUKH ADYSU ADZCM AENEX AFFNX AFKRA AFLOW AFRAH AFSHS AGAYW AGEZK AGHSJ AGHTU AGNAY AGSOS AHMBA AHSBF AIDAL AIDUJ AIYXT ALFFA ALIPV ALMA_UNASSIGNED_HOLDINGS AMTXH APEBS ARAPS ARMCB ARTTT ASPBG ATCPS ATWCN AVWKF AXYYD AZFZN AZQEC B-7 B0M BBNVY BCU BDKGC BEC BENPR BGLVJ BHPHI BIN BKEYQ BKKNO BKSAR BLC BPHCQ BVXVI C1K CCPQU CJ0 CS3 D1I D1J D1K DO4 DU5 DWQXO E.- E.L EAD EAP EAS EAZ EBC EBD EBO EBS ECC EE. EJD EMB EMF EMH EMK EMOBN EPL EPS ESE ESN ESTFP ESX EX3 EXGXG F5P FEDTE FQGFK FR3 FSGXE FYUFA GNUQQ GUQSH H94 HCIFZ HMCUK HVGLF HZ~ I-F IAO ICQ IEA IEP IGS IH2 IHR INH INR IOF IPY ISR ITC K6- K9. KB. KL. KOO L-9 L6V L7B LK5 LK8 LSO M0K M0L M1P M2M M2O M2P M7N M7P M7R M7S MBDVC N9A NAPCQ NEJ NEPJS O9- OBC OES OHH OHT OMK OVD P-O P2P P62 P64 PATMY PCBAR PDBOC PEA PM3 PQEST PQQKQ PQUKI PROAC PSQYO PSYQQ PTHSS PYCSY Q2X Q9U R05 RC3 RND RNS RNT RNTTT RXW S0X SC5 SHXYY SIXXV SJFOW SJN SNYQT SOI SV3 TAE TAOOD TBHMF TDRGL TEORI TH9 TN5 TSG TUS TWZ U5U UIG UKHRP UKR UMD UQL VQA VVN WH7 WOW X7M XIH XKW XZL Y6R YAE YCJ YFH YNT YOC YQT YR2 YXB YZZ ZCA ZE2 ZKB ~02 ~7V ~88 ~8M ~G0 ~KM |
ID | FETCH-proquest_journals_12234988173 |
IEDL.DBID | 8FG |
ISSN | 0028-0836 |
IngestDate | Tue Nov 19 06:41:08 EST 2024 |
IsPeerReviewed | true |
IsScholarly | true |
Issue | 7424 |
Language | English |
LinkModel | DirectLink |
MergedId | FETCHMERGED-proquest_journals_12234988173 |
PQID | 1223498817 |
PQPubID | 40569 |
ParticipantIDs | proquest_journals_1223498817 |
PublicationCentury | 2000 |
PublicationDate | 20121115 |
PublicationDateYYYYMMDD | 2012-11-15 |
PublicationDate_xml | – month: 11 year: 2012 text: 20121115 day: 15 |
PublicationDecade | 2010 |
PublicationPlace | London |
PublicationPlace_xml | – name: London |
PublicationTitle | Nature (London) |
PublicationYear | 2012 |
Publisher | Nature Publishing Group |
Publisher_xml | – name: Nature Publishing Group |
SSID | ssj0005174 |
Score | 4.2033105 |
Snippet | Pancreatic cancer is a highly lethal malignancy with few effective therapies. We performed exome sequencing and copy number analysis to define genomic... |
SourceID | proquest |
SourceType | Aggregation Database |
StartPage | 399 |
SubjectTerms | Animal models Carcinogenesis Genes Heterogeneity Medical research Mutation Pancreas Pancreatic cancer |
Title | Pancreatic cancer genomes reveal aberrations inaxonguidance pathway genes |
URI | https://www.proquest.com/docview/1223498817 |
Volume | 491 |
hasFullText | 1 |
inHoldings | 1 |
isFullTextHit | |
isPrint | |
link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfV3dS8MwED_chuCLuKn4MUtAH_QhaLq2SZ9Ex-oUHEMU-jbaNJU9rNVmQ_3vvXQZQ4S95CXJkeSSu18ulzuAC8HzNMWbDw2FSKmXi5CKLJNUIFjGDrngnvng_DwKhm_eU-zH1uCmrVvlSibWgjorpbGRXzPUYx4SZPz245OarFHmddWm0GhAi7k8MC59InpYu3j8j8L8V97WSiTag12L_sjdkl1t2FJFB7ZrL0ypO9C2J02TSxsO-mofHsfImBraSSINjypiAqvOsJUJv4TkklRVS0ZqMi2S77J4X0wz05SYhMNfyY_pofQBnEeD1_6QroY3sTtJT9bz7h1CsygLdQREuizwQyZUmOF1Rt2ELpdc5YgOVE9muX8M3U2UTjZXn8IOwgLX_Lhjfhea82qhzlD1zlMHGjzmWIo-c-q1dqB1PxiNX34BUfaOvg |
link.rule.ids | 314,780,784,12056,12223,12765,21388,31719,33266,33373,33744,43310,43579,43600,43805,73745,74014,74035,74302 |
linkProvider | ProQuest |
linkToHtml | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfV3fS8MwED60Q_RF3FT8MTWgD_oQtF27pk-istHpVoZM2Ftpk3TswVabDfW_99JlDBH2nORIcsndl-TyHcAV87M0xZMPDRhLqZuxgDIhOGUIlrFBxnxXf3AeRO3wzX0ee2Nz4aZMWOXSJlaGWhRc35Hf2ujHXBRo-_cfn1RnjdKvqyaFxibUNHO6Z0HtsRMNX1dBHv95mP9a3MqNdPdg1-A_8rBQWB02ZN6ArSoOk6sG1M1eU-TaEELf7ENviKqpwB0nXGupJJpa9R1raQImFJekslyoUpFpnnwX-WQ-Fboq0SmHv5If3UKqA7jsdkZPIV12LzZrScWrkbcOwcqLXB4B4Y7d9gKbyUDggUbeBY7PfZkhPpAtLjLvGJrrJJ2sL76A7XA06Mf9XvRyCjsIEhz9_872mmDNyrk8Q0c8S8_NbP8CZZmPwQ |
linkToPdf | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfV3dS8MwED-0Q_FF3FT8mBrQB30IW7t2TZ_Ej5XNj1JEYW9lzcfYg622G-p_76XLGCLsOckR7pK7X5Jf7gAumK_SFE8-NGAspa5iAWVCcMoQLOMAxXxXf3B-jrr9N_dh6A0N_6k0tMqFT6wctci5viNv2RjHXBRo-y1laBHxfXj98Ul1BSn90mrKaaxDDaNi27GgdtuL4pcl4eN_Tua_3rcKKeEObBssSG7mxqvDmswasFFxMnnZgLrZdyW5NMmhr3ZhEKOZKqDHCdcWK4hOs_qOvXQyJhQ3SmUxN2tJJtnoO8_Gs4nQXYkuP_w1-tEjZLkH52Hv9a5PF9NLzLoqk6UWOvtgZXkmD4Bwx-56gc1kIPBwI9uB43NfKsQKssOF8g6huUrS0ermM9hERSdPg-jxGLYQLzj6K57tNcGaFjN5gjF5mp4aZf8CVEST7g |
openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Pancreatic+cancer+genomes+reveal+aberrations+inaxonguidance+pathway+genes&rft.jtitle=Nature+%28London%29&rft.au=Biankin%2C+Andrew+V&rft.au=Waddell%2C+Nicola&rft.au=Kassahn%2C+Karin+S&rft.au=Gingras%2C+Marie-Claude&rft.date=2012-11-15&rft.pub=Nature+Publishing+Group&rft.issn=0028-0836&rft.eissn=1476-4687&rft.volume=491&rft.issue=7424&rft.spage=399&rft.externalDBID=HAS_PDF_LINK&rft.externalDocID=2834366461 |
thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0028-0836&client=summon |
thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0028-0836&client=summon |
thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0028-0836&client=summon |