Surface Display of N-Terminally Anchored Invasin by Lactobacillus plantarum Activates NF-[kappa]B in Monocytes

• Published in: Applied and environmental microbiology Vol. 78; no. 16; p. 5864
• Main Authors: Fredriksen, Lasse, Kleiveland, Charlotte R, Hult, Lene T Olsen, Lea, Tor, Nygaard, Cathrine S, Eijsink, Vincent GH, Mathiesen, Geir
• Format: Journal Article
• Language: English
• Published: Washington American Society for Microbiology 01.08.2012
• Subjects: Antigens; Cell culture; Cells; Peptides; Probiotics; Vaccines

The probiotic lactic acid bacterium Lactobacillus plantarum is a potential delivery vehicle for mucosal vaccines because of its generally regarded as safe (GRAS) status and ability to persist at the mucosal surfaces of the human intestine. However, the inherent immunogenicity of vaccine antigens is...