MicroRNA-181b regulates NF-[kappa]B-mediated vascular inflammation

• Published in: The Journal of clinical investigation Vol. 122; no. 6; p. 1973
• Main Authors: Sun, Xinghui, Icli, Basak, Wara, Akm Khyrul, Belkin, Nathan, He, Shaolin, Kobzik, Lester, Hunninghake, Gary M, Vera, Miguel Pinilla, Blackwell, Timothy S, Baron, Rebecca M, Feinberg, Mark W
• Format: Journal Article
• Language: English
• Published: Ann Arbor American Society for Clinical Investigation 01.06.2012
• Subjects: Biomedical research; Cytokines; Endothelium; Gene expression; Inflammation; Inflammatory diseases; Kinases; Leukocytes; MicroRNAs; Protein expression; Proteins; Sepsis; T cell receptors

EC activation and dysfunction have been linked to a variety of vascular inflammatory disease states. The function of microRNAs (miRNAs) in vascular EC activation and inflammation remains poorly understood. Herein, we report that microRNA-181b (miR-181b) serves as a potent regulator of downstream NF-...