The SDF-1 3'A Genetic Variation of the Chemokine SDF-1[alpha] (CXCL12) in Parallel with its Increased Circulating Levels is Associated with Susceptibility to MS: A Study on Iranian Multiple Sclerosis Patients

• Published in: Journal of molecular neuroscience Vol. 47; no. 3; p. 431
• Main Authors: Azin, Hossein, Vazirinejad, Reza, Ahmadabadi, Behzad Nasiri, Khorramdelazad, Hossein, Zarandi, Ebrahim Rezazadeh, Arababadi, Mohammad Kazemi, Karimabad, Mojgan Noroozi, Shamsizadeh, Ali, Rafatpanah, Houshang, Hassanshahi, Gholamhossein
• Format: Journal Article
• Language: English
• Published: Totowa Springer Nature B.V 01.07.2012
• Subjects: Alzheimer's disease; Chemokines; DNA polymerase; Genetic testing; Immune system; Medicine; Multiple sclerosis; Pathogenesis; Polymorphism; Research centers; Iran

Immune system-related factors are important in pathogenesis of multiple sclerosis. The CXC chemokine SDF-1α (CXCL12) is involved in the immune responses. Hence, the aim of this study was to investigate the association between serum levels of SDF-1α (CXCL12) and its gene polymorphisms at position +80...