Laminin/[beta]1 integrin signal triggers axon formation by promoting microtubule assembly and stabilization

• Published in: Cell research Vol. 22; no. 6; p. 954
• Main Authors: Lei, Wen-liang, Xing, Shi-ge, Deng, Cai-yun, Ju, Xiang-chun, Jiang, Xing-yu, Luo, Zhen-ge
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group 01.06.2012
• Subjects: Polarization

Axon specification during neuronal polarization is closely associated with increased microtubule stabilization in one of the neurites of unpolarized neuron, but how this increased microtubule stability is achieved is unclear. Here, we show that extracellular matrix (ECM) component laminin promotes n...