Herpesvirus Genome Recognition Induced Acetylation of Nuclear IFI16 Is Essential for Its Cytoplasmic Translocation, Inflammasome and IFN-[Beta] Responses

• Published in: PLoS pathogens Vol. 11; no. 7
• Main Authors: Ansari, Mairaj, Dutta, Sujoy, Veettil, Mohanan, Dutta, Dipanjan, Iqbal, Jawed, Kumar, Binod, Roy, Arunava, Chikoti, Leela, Singh, Vivek, Chandran, Bala
• Format: Journal Article
• Language: English
• Published: Public Library of Science 01.07.2015
• Subjects: Cytokines; Cytoplasm; Cytotoxicity; Deoxyribonucleic acid; DNA; Experiments; Funding; Genomes; Immunoglobulins; Infections; Proteins; Sensors; Studies

  The IL-1[Beta] and type I interferon-[Beta] (IFN-[Beta]) molecules are important inflammatory cytokines elicited by the eukaryotic host as innate immune responses against invading pathogens and danger signals. Recently, a predominantly nuclear gamma-interferon-inducible protein 16 (IFI16) involved...