The Structural Basis of Gas-Responsive Transcription by the Human Nuclear Hormone Receptor REV-ERB[beta]
Heme is a ligand for the human nuclear receptors (NR) REV-ERBα and REV-ERBβ, which are transcriptional repressors that play important roles in circadian rhythm, lipid and glucose metabolism, and diseases such as diabetes, atherosclerosis, inflammation, and cancer. Here we show that transcription r...
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Published in | PLoS biology Vol. 7; no. 2 |
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Main Authors | , , , , , , , , , , , , |
Format | Journal Article |
Language | English |
Published |
Public Library of Science
01.02.2009
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Subjects | |
Online Access | Get full text |
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