The Structural Basis of Gas-Responsive Transcription by the Human Nuclear Hormone Receptor REV-ERB[beta]

• Published in: PLoS biology Vol. 7; no. 2
• Main Authors: Pardee, Keith, Xu, Xiaohui, Reinking, Jeff, Schuetz, Anja, Dong, Aiping, Liu, Suya, Zhang, Rongguang, Tiefenbach, Jens, Lajoie, Gilles, Plotnikov, Alexander, Botchkarev, Alexey, Krause, Henry, Edwards, Aled
• Format: Journal Article
• Language: English
• Published: Public Library of Science 01.02.2009
• Subjects: Apolipoproteins; Atherosclerosis; Brain research; Cancer; Circadian rhythm; Diabetes; Insects; Ligands; Medical research; Nitric oxide; Proteins; Rodents; Protein Structure, Tertiary; Oxidation-Reduction; Humans; Repressor Proteins; Transcriptional Activation; Nitric Oxide; Circadian Rhythm; Protein Interaction Domains & Motifs; Heme; Cell Line, Tumor; Ligands; Transcription, Genetic; Transcription Factors; Binding Sites; DNA-Binding Proteins; Receptors, Cytoplasmic & Nuclear

  Heme is a ligand for the human nuclear receptors (NR) REV-ERBα and REV-ERBβ, which are transcriptional repressors that play important roles in circadian rhythm, lipid and glucose metabolism, and diseases such as diabetes, atherosclerosis, inflammation, and cancer. Here we show that transcription r...