Discovery of 6-Aryl-7-alkoxyisoquinoline Inhibitors of IKB Kinase-β (IKK-β)

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Published inJournal of medicinal chemistry Vol. 52; no. 9; pp. 3098 - 3102
Main Authors CHRISTOPHER, John A, BAMBOROUGH, Paul, MELLOR, Geoffrey W, MILLER, David D, MORSE, Mary A, PANCHOLI, Kiritkant D, RUMSEY, William, SOLANKE, Yemisi E, WILLIAMSON, Rick, ALDER, Catherine, CAMPBELL, Amanda, CUTLER, Geoffrey J, DOWN, Kenneth, HAMADI, Ahmed M, JOLLY, Adrian M, KERNS, Jeffrey K, LUCAS, Fiona S
Format Journal Article
LanguageEnglish
Published Columbus, OH American Chemical Society 2009
Subjects
Biological and medical sciences
Bones, joints and connective tissue. Antiinflammatory agents
Medical sciences
Pharmacology. Drug treatments
Isoquinoline derivatives
Ether
Enzyme
Transferases
Non-specific serine/threonine protein kinase
Cytokine
Selectivity
In vitro
Modeling
Signal transduction
Structure activity relation
Piperidine derivatives
Molecular model
Inhibitor
Transcription factor NFκB
Small molecule
Chemical synthesis
Tumor necrosis factor α
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Author RUMSEY, William
SOLANKE, Yemisi E
WILLIAMSON, Rick
CHRISTOPHER, John A
CAMPBELL, Amanda
LUCAS, Fiona S
MILLER, David D
PANCHOLI, Kiritkant D
BAMBOROUGH, Paul
KERNS, Jeffrey K
ALDER, Catherine
HAMADI, Ahmed M
JOLLY, Adrian M
MORSE, Mary A
DOWN, Kenneth
CUTLER, Geoffrey J
MELLOR, Geoffrey W
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  givenname: Paul
  surname: BAMBOROUGH
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  givenname: Geoffrey W
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  givenname: Kiritkant D
  surname: PANCHOLI
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  organization: GlaxoSmithKline R&D, New Frontiers Science Park, Third Avenue, Harlow, Essex, CM19 5AW, United Kingdom
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  organization: GlaxoSmithKline Inc., 709 Swedeland Road, King of Prussia, Pennsylvania 19406, United States
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  givenname: Yemisi E
  surname: SOLANKE
  fullname: SOLANKE, Yemisi E
  organization: GlaxoSmithKline R&D, Medicines Research Centre, Gunnels Wood Road, Stevenage, Hertfordshire, SG1 2NY, United Kingdom
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  givenname: Catherine
  surname: ALDER
  fullname: ALDER, Catherine
  organization: GlaxoSmithKline R&D, Medicines Research Centre, Gunnels Wood Road, Stevenage, Hertfordshire, SG1 2NY, United Kingdom
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  givenname: Amanda
  surname: CAMPBELL
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  surname: DOWN
  fullname: DOWN, Kenneth
  organization: GlaxoSmithKline R&D, Medicines Research Centre, Gunnels Wood Road, Stevenage, Hertfordshire, SG1 2NY, United Kingdom
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  givenname: Ahmed M
  surname: HAMADI
  fullname: HAMADI, Ahmed M
  organization: GlaxoSmithKline R&D, Medicines Research Centre, Gunnels Wood Road, Stevenage, Hertfordshire, SG1 2NY, United Kingdom
– sequence: 15
  givenname: Adrian M
  surname: JOLLY
  fullname: JOLLY, Adrian M
  organization: GlaxoSmithKline R&D, Medicines Research Centre, Gunnels Wood Road, Stevenage, Hertfordshire, SG1 2NY, United Kingdom
– sequence: 16
  givenname: Jeffrey K
  surname: KERNS
  fullname: KERNS, Jeffrey K
  organization: GlaxoSmithKline Inc., 709 Swedeland Road, King of Prussia, Pennsylvania 19406, United States
– sequence: 17
  givenname: Fiona S
  surname: LUCAS
  fullname: LUCAS, Fiona S
  organization: GlaxoSmithKline R&D, Medicines Research Centre, Gunnels Wood Road, Stevenage, Hertfordshire, SG1 2NY, United Kingdom
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Issue 9
Keywords Isoquinoline derivatives
Ether
Enzyme
Transferases
Non-specific serine/threonine protein kinase
Cytokine
Selectivity
In vitro
Modeling
Signal transduction
Structure activity relation
Piperidine derivatives
Molecular model
Inhibitor
Transcription factor NFκB
Small molecule
Chemical synthesis
Tumor necrosis factor α
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PublicationYear 2009
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StartPage 3098
SubjectTerms Biological and medical sciences
Bones, joints and connective tissue. Antiinflammatory agents
Medical sciences
Pharmacology. Drug treatments
Title Discovery of 6-Aryl-7-alkoxyisoquinoline Inhibitors of IKB Kinase-β (IKK-β)
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