Identification of 2-{2-[2-(5-bromo-2-methoxyphenyl)-ethyl]-3-fluorophenyl}-4,5-dihydro-1H-imidazol e (ML00253764), a small molecule melanocortin 4 receptor antagonist that effectively reduces tumor-induced weight loss in a mouse model
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| Published in | Journal of medicinal chemistry Vol. 47; no. 7; pp. 1602 - 1604 |
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| Main Authors | , , , , , , , , , , , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
Washington, DC
American Chemical Society
2004
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| Subjects | |
| Online Access | Get full text |
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| Author | HORLICK, Robert A CARACOTI, Andrei YOWE, David L BALANI, Suresh CHE, Jennifer L DRABIC, Stacey V JOSEPH, Ingrid B. J. K VOS, Tricia J PATANE, Michael A MAGUIRE, Martin P CLAIBORNE, Christopher F HANG ZENG RODRIGUEZ, Luis E FARRER, Cheryl A DAI, Mingshi PING LI FORSYTH, Nancy E LAMPPU, Diana |
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| Keywords | Imidazole derivatives Intravenous administration Nitrogen heterocycle Body weight Central nervous system Non peptide compound Encephalon Tissue Subcutaneous administration Antagonist Chemical synthesis Rodentia Weight loss Organic bromine compounds Malignant tumor Biological activity Vertebrata Amidine Mammalia MC4 melanocortin receptor Mouse Animal Distribution Organic fluorine compounds Benzenic compound Pharmacokinetics |
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| SubjectTerms | Biological and medical sciences Medical sciences Neuropharmacology Neurotransmitters. Neurotransmission. Receptors Peptidergic system (neuropeptide, opioid peptide, opiates...). Adenosinergic and purinergic systems Pharmacology. Drug treatments |
| Title | Identification of 2-{2-[2-(5-bromo-2-methoxyphenyl)-ethyl]-3-fluorophenyl}-4,5-dihydro-1H-imidazol e (ML00253764), a small molecule melanocortin 4 receptor antagonist that effectively reduces tumor-induced weight loss in a mouse model |
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