Mapping on human and mouse chromosomes of the gene of the [beta]-galactoside-binding protein, an autocrine-negative growth factor

The structural gene for 6-galactoside-binding protein (Lgals-1), a cell growth regulatory molecule and cytostatic factor, is assigned to the E-region of mouse chromosome 15 and to the region q12-q13.1 of human chromosome 22. The evolutionary conservation of these two regions has been previously sugg...

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Published inGenomics (San Diego, Calif.) Vol. 15:1
Main Authors Baldini, A., Muresu, R., Siniscalco, M., Gress, T., Patel, K., Casciano, I., Chiariotti, L., Bruni, C.B., Williamson, P., Boyd, Y., Wells, V., Mallucci, L.
Format Journal Article
LanguageEnglish
Published United States 01.01.1993
Subjects
ANIMAL CELLS
BASIC BIOLOGICAL SCIENCES
CHROMOSOMES
CONTROL
GENES
GENETIC MAPPING
GROWTH
HUMAN CHROMOSOME 22
HUMAN CHROMOSOMES
MAPPING 550400 > Genetics
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Summary:The structural gene for 6-galactoside-binding protein (Lgals-1), a cell growth regulatory molecule and cytostatic factor, is assigned to the E-region of mouse chromosome 15 and to the region q12-q13.1 of human chromosome 22. The evolutionary conservation of these two regions has been previously suggested from comparative mapping of several loci. These include the murine SIS oncogene (Pdgfb) and its human homolog, the platelet-derived growth factor-[beta] polypeptide, PDGFB. The findings presented here extend the genetic homology of the two regions. 12 refs., 1 figs.
Bibliography:None
ISSN:0888-7543
1089-8646
DOI:10.1006/geno.1993.1039