Cystic fibrosis gene expression is not correlated with rectifying Cl sup minus channels

• Published in: Proceedings of the National Academy of Sciences - PNAS Vol. 88:12
• Main Authors: Ward, C.L., Krouse, M.E., Kopito, R.R., Wine, J.J., Gruenert, D.C.
• Format: Journal Article
• Language: English
• Published: United States 15.06.1991
• Subjects: 550200 - Biochemistry; ANIMAL TISSUES; ANIMALS; BASIC BIOLOGICAL SCIENCES; BODY; CHLORIDES; CHLORINE COMPOUNDS; DISEASES; DNA POLYMERASES; ENZYMES; EPITHELIUM; ETIOLOGY; FIBROSIS; GENE REGULATION; HALIDES; HALOGEN COMPOUNDS; HEREDITARY DISEASES; MAMMALS; MAN; MEMBRANE TRANSPORT; MESSENGER-RNA; NUCLEIC ACIDS; NUCLEOTIDYLTRANSFERASES; ORGANIC COMPOUNDS; PATHOLOGICAL CHANGES; PERMEABILITY; PHOSPHORUS-GROUP TRANSFERASES; POLYMERASES; PRIMATES; PROTEINS; RNA; TISSUES; TRANSFERASES; VERTEBRATES

Cystic fibrosis (CF) involves a profound reduction of Cl{sup {minus}} permeability in several exocrine tissues. A distinctive, outwardly rectifying, depolarization-induced Cl{sup {minus}} channel (ORDIC channel) has been proposed to account for the Cl{sup {minus}} conductance that is defective in CF...