Characterization of an sup 125 I-labeled thromboxane A2/prostaglandin H2 receptor agonist

• Published in: The Journal of pharmacology and experimental therapeutics Vol. 251:2
• Main Authors: Morinelli, T.A., Oatis, J.E. Jr, Okwu, A.K., Mais, D.E., Mayeux, P.R., Masuda, A., Knapp, D.R., Halushka, P.V.
• Format: Journal Article
• Language: English
• Published: United States 01.11.1989
• Subjects: 550201 - Biochemistry- Tracer Techniques; AFFINITY; ANIMALS; BASIC BIOLOGICAL SCIENCES; BETA DECAY RADIOISOTOPES; BIOCHEMICAL REACTION KINETICS; BIOLOGICAL MATERIALS; BLOOD; BLOOD CELLS; BLOOD PLATELETS; BLOOD VESSELS; BODY; BODY FLUIDS; CARDIOVASCULAR SYSTEM; CHEMICAL COMPOSITION; DAYS LIVING RADIOISOTOPES; ELECTRON CAPTURE RADIOISOTOPES; INTERMEDIATE MASS NUCLEI; IODINE 125; IODINE ISOTOPES; ISOTOPES; KINETICS; MAMMALS; MAN; MATERIALS; MEMBRANE PROTEINS; MUSCLES; NUCLEI; ODD-EVEN NUCLEI; ORGANIC COMPOUNDS; ORGANS; PRIMATES; PROSTAGLANDINS; PROTEINS; RADIOASSAY; RADIOISOTOPES; REACTION KINETICS; RECEPTORS; VERTEBRATES

Stable synthetic mimetics of thromboxane (TX) A2 and prostaglandin (PG) H2 have been synthesized and reported to stimulate platelets and vascular smooth muscle. The synthetic agonists induce aggregation of isolated platelets and contraction of vascular tissue. The tritiated agonists (3H)U46619 and (...