Design and Validation of In-Source Atmospheric Pressure Photoionization Hydrogen/Deuterium Exchange Mass Spectrometry with Continuous Feeding of D{sub 2}O

• Published in: Journal of the American Society for Mass Spectrometry Vol. 29; no. 1
• Main Authors: Acter, Thamina, Lee, Seulgidaun, Cho, Eunji, Jung, Maeng-Joon, Kim, Sunghwan
• Format: Journal Article
• Language: English
• Published: United States 15.01.2018
• Subjects: ATMOSPHERIC PRESSURE; CAPILLARIES; DEUTERIUM; HEAVY WATER; HYDROGEN; INORGANIC, ORGANIC, PHYSICAL AND ANALYTICAL CHEMISTRY; INSTRUMENTATION RELATED TO NUCLEAR SCIENCE AND TECHNOLOGY; MATHEMATICAL SOLUTIONS; NITROGEN; OXYGEN; PETROLEUM; PHOTOIONIZATION; SULFUR COMPOUNDS; VALIDATION

In this study, continuous in-source hydrogen/deuterium exchange (HDX) atmospheric pressure photoionization (APPI) mass spectrometry (MS) with continuous feeding of D{sub 2}O was developed and validated. D{sub 2}O was continuously fed using a capillary line placed on the center of a metal plate posit...