Hypoxia-inducible factor 1 mediates hypoxia-induced cardiomyocyte lipid accumulation by reducing the DNA binding activity of peroxisome proliferator-activated receptor {alpha}/retinoid X receptor

• Published in: Biochemical and biophysical research communications Vol. 364; no. 3
• Main Authors: Belanger, Adam J., Luo Zhengyu, Vincent, Karen A., Akita, Geoffrey Y., Cheng, Seng H., Gregory, Richard J., Jiang Canwen
• Format: Journal Article
• Language: English
• Published: United States 21.12.2007
• Subjects: 60 APPLIED LIFE SCIENCES; ADENOVIRUS; ANOXIA; ATP; CARNITINE; DNA; ENZYMES; GLUCOSE; GLYCOLYSIS; HYBRIDIZATION; LIGANDS; LIPIDS; MITOCHONDRIA; MUSCLES; OXIDATION; RECEPTORS

In response to cellular hypoxia, cardiomyocytes adapt to consume less oxygen by shifting ATP production from mitochondrial fatty acid {beta}-oxidation to glycolysis. The transcriptional activation of glucose transporters and glycolytic enzymes by hypoxia is mediated by hypoxia-inducible factor 1 (HI...