Influence of the irradiated pulmonary microenvironment on macrophage and T cell dynamics

• Published in: Radiotherapy and oncology Vol. 183
• Main Authors: Groves, Angela M., Misra, Ravi, Clair, Geremy, Hernady, Eric, Olson, Heather M., Orton, Daniel J., Finkelstein, Jacob N., Marples, Brian, Johnston, Carl J.
• Format: Journal Article
• Language: English
• Published: United States Elsevier 20.02.2023
• Subjects: macrophage; microenvironment; radiation induced lung injury; RADIOLOGY AND NUCLEAR MEDICINE

The lung is sensitive to radiation, which increases the risk of normal tissue toxicity following radiation therapy. Adverse outcomes include pneumonitis and pulmonary fibrosis, which are thought to result from dysregulated intercellular communication within the pulmonary microenvironment. Macrophage...