High-Resolution Structure of a Self-Assembly-Competent Form of a Hydrophobic Peptide Captured in a Soluble [beta]-Sheet Scaffold

• Published in: Journal of molecular biology Vol. 378; no. (2) ; 04, 2008
• Main Authors: Makabe, Koki, Biancalana, Matthew, Yan, Shude, Tereshko, Valentina, Gawlak, Grzegorz, Miller-Auer, Hélène, Meredith, Stephen C., Koide, Shohei
• Format: Journal Article
• Language: English
• Published: United States 08.02.2010
• Subjects: AQUEOUS SOLUTIONS; CRYSTAL STRUCTURE; MATERIALS SCIENCE; PEPTIDES; POLYPEPTIDES; PROTEINS; STABILITY

{beta}-Rich self-assembly is a major structural class of polypeptides, but still little is known about its atomic structures and biophysical properties. Major impediments for structural and biophysical studies of peptide self-assemblies include their insolubility and heterogeneous composition. We ha...