A novel herbal formulation consisting of red ginseng extract and Epimedium koreanum Nakaiattenuated dextran sulfate sodium-induced colitis in mice
Background: Ulcerative colitis (UC) is a commonly encountered large intestine disease in the contemporaryworld that terminates into colorectal cancer; therefore, the timely treatment of UC is of majorconcern. Panax ginseng Meyer is an extensively consumed herbal commodity in South East Asiancountrie...
Saved in:
Published in | Journal of ginseng research pp. 833 - 842 |
---|---|
Main Authors | , , , , , , , , |
Format | Journal Article |
Language | English |
Published |
고려인삼학회
01.11.2020
|
Subjects | |
Online Access | Get full text |
Cover
Loading…
Abstract | Background: Ulcerative colitis (UC) is a commonly encountered large intestine disease in the contemporaryworld that terminates into colorectal cancer; therefore, the timely treatment of UC is of majorconcern. Panax ginseng Meyer is an extensively consumed herbal commodity in South East Asiancountries, especially Korea. It exhibits a wide range of biologically beneficial qualities for almost head-totoeailments in the body. Epimedium koreanum Nakai (EKN) is also a widely used traditional Koreanherbal medicine used for treating infertility, rheumatism, and cardiovascular diseases.
Materials and methods: Separately the anti-inflammatory activities of both red ginseng extracts (RGEs)and EKNs had been demonstrated in the past in various inflammatory models; however, we sought tounravel the anti-inflammatory activities of the combination of these two extracts in dextran sulfatesodium (DSS)-induced ulcerative colitis in mice model because the allopathic remedies for UC involvemore side effects than benefits.
Results: Our results have shown that the combination of RGE þ EKN synergistically alleviated themacroscopic lesions in DSS-induced colitic mice such as colon shortening, hematochezia, and weightloss. Moreover, it restored the histopathological lesions in mice and decreased the levels of proinflammatorymediators and cytokines through the repression of nuclear factor kappa-light-chainenhancerof activated B cells (NF-kB) and nucleotide-binding domain (NOD)-like receptor protein 3(NLRP-3) expression. In vitro, this combination also reduced the magnitude of nitric acid (NO), proinflammatorymediators and cytokine through NF-kB and mitogen-activated protein kinase (MAPK)pathways in RAW 264.7 mouse macrophage cells.
Conclusion: In the light of these findings, we can endorse this combination extract as a functional foodfor the prophylactic as well as therapeutic treatment of UC in humans together with allopathic remedies. KCI Citation Count: 13 |
---|---|
AbstractList | Background: Ulcerative colitis (UC) is a commonly encountered large intestine disease in the contemporaryworld that terminates into colorectal cancer; therefore, the timely treatment of UC is of majorconcern. Panax ginseng Meyer is an extensively consumed herbal commodity in South East Asiancountries, especially Korea. It exhibits a wide range of biologically beneficial qualities for almost head-totoeailments in the body. Epimedium koreanum Nakai (EKN) is also a widely used traditional Koreanherbal medicine used for treating infertility, rheumatism, and cardiovascular diseases.
Materials and methods: Separately the anti-inflammatory activities of both red ginseng extracts (RGEs)and EKNs had been demonstrated in the past in various inflammatory models; however, we sought tounravel the anti-inflammatory activities of the combination of these two extracts in dextran sulfatesodium (DSS)-induced ulcerative colitis in mice model because the allopathic remedies for UC involvemore side effects than benefits.
Results: Our results have shown that the combination of RGE þ EKN synergistically alleviated themacroscopic lesions in DSS-induced colitic mice such as colon shortening, hematochezia, and weightloss. Moreover, it restored the histopathological lesions in mice and decreased the levels of proinflammatorymediators and cytokines through the repression of nuclear factor kappa-light-chainenhancerof activated B cells (NF-kB) and nucleotide-binding domain (NOD)-like receptor protein 3(NLRP-3) expression. In vitro, this combination also reduced the magnitude of nitric acid (NO), proinflammatorymediators and cytokine through NF-kB and mitogen-activated protein kinase (MAPK)pathways in RAW 264.7 mouse macrophage cells.
Conclusion: In the light of these findings, we can endorse this combination extract as a functional foodfor the prophylactic as well as therapeutic treatment of UC in humans together with allopathic remedies. KCI Citation Count: 13 |
Author | 김민기 Yuan Yee Lee 김동선 Sun Hee Hyun Chae Kyu Park Eunjung Son 김성대 MAN HEE RHEE Evelyn Saba |
Author_xml | – sequence: 1 fullname: Evelyn Saba organization: (경북대학교) – sequence: 2 fullname: Yuan Yee Lee organization: (경북대학교) – sequence: 3 fullname: 김민기 organization: (경북대학교) – sequence: 4 fullname: Sun Hee Hyun organization: (KT&G Central Research Institute) – sequence: 5 fullname: Chae Kyu Park organization: (KGC R&D Headquarters) – sequence: 6 fullname: Eunjung Son organization: (Korea Institute of Oriental Medicine) – sequence: 7 fullname: 김동선 organization: (한국한의학연구원) – sequence: 8 fullname: 김성대 organization: (동남권원자력의학원) – sequence: 9 fullname: MAN HEE RHEE organization: (Kyungpook National University) |
BackLink | https://www.kci.go.kr/kciportal/ci/sereArticleSearch/ciSereArtiView.kci?sereArticleSearchBean.artiId=ART002645670$$DAccess content in National Research Foundation of Korea (NRF) |
BookMark | eNqVi81OhDAUhRszJjLqA7i7WxfUUrDIcmLGOBsXZvakloIXyq1pi_E5fGJx4gu4On_f2bINebKM3RSCF6JQdyMfh8ClkIILyYUoz1gmRVPmVVPVG5YVUqr8obovL9g2xlEIVcu6ytj3Dsh_WgfvNrxpB70P8-J0Qk9gPEWMCWkA30OwHQxI0a7RfqWgTQJNHew_cLYdLjNMPlhNq3nRk0adkqVFp_XWnXiCuLh-LSD6Xz5H6hazzsY7TBgBCWY09oqd99pFe_2nl-z2aX98fM4p9O1ksPUaTzr4dgrt7vV4aBslSqWK8j_sDwxvZbA |
ContentType | Journal Article |
DBID | ACYCR |
DOI | 10.1016/j.jgr.2020.02.003 |
DatabaseName | Korean Citation Index |
DatabaseTitleList | |
DeliveryMethod | fulltext_linktorsrc |
Discipline | Agriculture |
EISSN | 2093-4947 |
EndPage | 842 |
ExternalDocumentID | oai_kci_go_kr_ARTI_9603661 |
GroupedDBID | .UV 0SF 4.4 457 5VS 6I. 9ZL AACTN AAEDT AAEDW AAFTH AAHBH AAIKJ AALRI AAXUO AAYYP ABMAC ACGFS ACYCR ADEZE ADRAZ AENEX AEXQZ AFTJW AGHFR AITUG AKRWK ALMA_UNASSIGNED_HOLDINGS AMRAJ DBRKI DIK EBS EJD F5P FDB GROUPED_DOAJ GX1 HYE IPNFZ IXB JDI KQ8 KVFHK M48 M~E NCXOZ RIG ROL RPM SSZ TDB |
ID | FETCH-nrf_kci_oai_kci_go_kr_ARTI_96036613 |
IEDL.DBID | M48 |
ISSN | 1226-8453 |
IngestDate | Tue Jun 25 21:04:54 EDT 2024 |
IsPeerReviewed | true |
IsScholarly | true |
Language | English |
LinkModel | DirectLink |
MergedId | FETCHMERGED-nrf_kci_oai_kci_go_kr_ARTI_96036613 |
ParticipantIDs | nrf_kci_oai_kci_go_kr_ARTI_9603661 |
PublicationCentury | 2000 |
PublicationDate | 2020-11 |
PublicationDateYYYYMMDD | 2020-11-01 |
PublicationDate_xml | – month: 11 year: 2020 text: 2020-11 |
PublicationDecade | 2020 |
PublicationTitle | Journal of ginseng research |
PublicationYear | 2020 |
Publisher | 고려인삼학회 |
Publisher_xml | – name: 고려인삼학회 |
SSID | ssj0067274 |
Score | 4.462012 |
Snippet | Background: Ulcerative colitis (UC) is a commonly encountered large intestine disease in the contemporaryworld that terminates into colorectal cancer;... |
SourceID | nrf |
SourceType | Open Website |
StartPage | 833 |
SubjectTerms | 기타의약학 |
Title | A novel herbal formulation consisting of red ginseng extract and Epimedium koreanum Nakaiattenuated dextran sulfate sodium-induced colitis in mice |
URI | https://www.kci.go.kr/kciportal/ci/sereArticleSearch/ciSereArtiView.kci?sereArticleSearchBean.artiId=ART002645670 |
hasFullText | 1 |
inHoldings | 1 |
isFullTextHit | |
isPrint | |
ispartofPNX | Journal of Ginseng Research, 2020, 44(6), , pp.833-842 |
link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwjV1LT4NAEN7U9qIH4zM-m4nx4gGDsFA4GNM0bapJ68UmjRcC7NIguCgUo3_DX-wMpeqhiZ54ZLKE2WXnG2bmG8bOue2IyDJcDb02S-O-q2uuvHJxM7QsKW2nE9pUjTwa28MJv5ta0wZbtreqFVisdO2on9QkTy_fXz9u8IO__snVepoRtaehL-g3zTXWMrjJacGP-HdQgWKOVZAZEYfmcMtcBjlXDYGmRuXRL1Mz2GKbNUaE7mJSt1lDqh220Z3lNU-G3GWfXVDZm0wBVR6gLEHPuhEXhJTzWlA6M2QR5FIA_VSWeIkbMRVFga8E9F9iiquXz5BkCBwVnoz9xI-Jb1OViEAFiEpeQVGmEd6AIiN5Db14XA8Cn0OpcwXECqin_R67GPQfekMN38hLwtgjSmk6zjIvyT0EzrceOjImmmpznzVVpuQBA53L0BHcCALH5MIPA10EdkdIw-z4duTqh-zs7_GO_iN0zNZJ84sKvxPWnOelPEVTPw_alYvcrqaxzVrj3vT-8QvIsbID |
link.rule.ids | 315,786,790,870,24346,27957,27958 |
linkProvider | Scholars Portal |
openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=A+novel+herbal+formulation+consisting+of+red+ginseng+extract+and+Epimedium+koreanum+Nakaiattenuated+dextran+sulfate+sodium-induced+colitis+in+mice&rft.jtitle=Journal+of+ginseng+research&rft.au=Evelyn+Saba&rft.au=Yuan+Yee+Lee&rft.au=%EA%B9%80%EB%AF%BC%EA%B8%B0&rft.au=Sun+Hee+Hyun&rft.date=2020-11-01&rft.pub=%EA%B3%A0%EB%A0%A4%EC%9D%B8%EC%82%BC%ED%95%99%ED%9A%8C&rft.issn=1226-8453&rft.eissn=2093-4947&rft.spage=833&rft.epage=842&rft_id=info:doi/10.1016%2Fj.jgr.2020.02.003&rft.externalDBID=n%2Fa&rft.externalDocID=oai_kci_go_kr_ARTI_9603661 |
thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=1226-8453&client=summon |
thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=1226-8453&client=summon |
thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=1226-8453&client=summon |