비강 및 부비동 종양에서의 p53, p21, Cyclin D1, Ki-67 발현

• Published in: Journal of rhinology pp. 108 - 114
• Main Authors: 정하민, 윤기중, 이재훈
• Format: Journal Article
• Language: Korean
• Published: 대한비과학회 01.11.2008
• Subjects: 이비인후과학
• ISSN: 1229-1498; 2384-4361

Background and Objectives：The goal of this study is to investigate alterations of cell-cycle-related molecules, including p53, p21, cyclin D1 and Ki-67, in tumors arising in the sinonasal region. Materials and Methods：The study materials were 16 specimens of normal nasal mucosa, 16 inverted papillomas (IPs) and 12 sinonasal squamous cell carcinomas. The p53, p21, cyclin D1 and Ki-67 expression was assessed by immunohistochemical staining. Result：IP and squamous cell carcinoma showed significant increase in the expression of p53, cyclin D1 and Ki-67 than normal mucosa. The expression of p53, cyclin D1 and Ki-67 of the carcinoma was stronger than the IP. But, the p21 expression was not associated with the IP and carcinoma. Conclusion：Increased levels of p53, cyclin D1 and Ki-67 expression correlate with increased cell proliferation in the tumors of sinonasal regions. These findings indicate that p53, cyclin D1 and Ki-67 expression may be useful markers for the dysregulations of cell kinetics in the tumors of sinonasal region. KCI Citation Count: 0