위점막의 이형성의 유형과 조기 위암의 조직학적 유형과의 연관성

• Published in: Kosin Medical Journal (Online) pp. 135 - 156
• Main Authors: 장희경, 허만하
• Format: Journal Article
• Language: Korean
• Published: 고신대학교 의과대학 학술지 01.09.1992
• Subjects: 의학일반
• ISSN: 2005-9531; 2586-7024

-Abstract- This study was performed to elucidate the relationship of types of dysplasia and histological types of early gastric cancer. And, the correlations between types of gastric dysplasia and sex and age were evaluated. The materials were 141 cases of surgical specimens of early gastric cancer submitted to Department of Pathology following gastrectomy at Kosin Medical Center during 5 years from 1984 to 1989. The results were summarized as follows : 1. The histologic types and incidence of 141 cases of early gastric cancer(EGC) by Lauren system were : diffuse type 59 cases(41.84%) ; intermediate type 41 cases(29.08%) ; and intestinal type 41 cases(29.08%). The mean age for the histologic types was 49 years in diffuse type, 51 years intermediate type, and 54 years in intestinal type. Mean age of EGC overall was 51 years. 2. The types of gastric dysplasia in gastric mucosa adjacent to EGC lesions were classified by the proposed standard of Ghandur-Mnaymneh into metaplastic dysplasia(97 cases:68.8%) and nonmetaplastic dysplasia(98 cases: 69.50%). Among these, the cases of simultaneous presentation of both dysplasias were 55 cases (39.00%). The severity of the changes was graded by the basis of Ghandur-Mnaymneh in nonmetaplastic dysplasia and the proposal of WHO expert committee in metaplastic dysplasia. The cases showing severity of more than moderate degree were 82 cases(58.20%) in metaplastic dysplasia and 86 cases(60.99%) in nonmetaplastic dysplasia. 3. In cases of metaplastic dysplasia, age and frequency and severity showed positive correlation. 4. In relationship of histologic types of EGC and types of gastric dysplasia, the frequency of nonmetaplastic dysplasia in diffuse and intermediate type carcinoma was significantly higher than the corresponding frequency in intestinal type carcinoma, and the frequency of metaplastic dysplasia in intestinal type carcinoma was significantly higher than corresponding frequency of diffuse and intermediate type carcinoma. 5. The frequency and severity of metaplastic dysplasia of Intermediate type carcinoma was between diffuse type and intestinal type carcinoma, but in frequency and severity, no significant difference in nonmetaplastic dysplasia from diffuse type carcinoma was seen. With the above results, we suggest intermediate type of EGC shows a higher association with diffuse type than intestinal type in histopathogenesis. KCI Citation Count: 0