근육위축 가쪽경화증 수부분할현상의 신경생리분석

• Published in: 대한근전도 전기진단의학회지, 19(2) pp. 61 - 66
• Main Authors: 권수연, 김창환
• Format: Journal Article
• Language: Korean
• Published: 대한근전도전기진단의학회 01.12.2017
• Subjects: 재활의학
• ISSN: 2733-6581; 2733-659X
• DOI: 10.18214/jkaem.2017.19.2.61

Objective: We investigated the clinical and electrophysiological expressions of the thenar muscular atrophy in patients with amyotrophic lateral sclerosis (ALS) and evaluated whether the selective involvement of thenar muscles was caused by the split hand phenomenon or by overlapping peripheral neuropathies. Method: We retrospectively compared electrophysiologic data of 35 ALS patients to 50 age-matched healthy control subjects. We further compared electrophysiologic data of the ALS patients with peripheral neuropathies to those who had none, to evaluate the influence of concurrent peripheral neuropathies on the thenar muscular atrophy. Results: All ALS patients showed prolonged motor latencies and decreased sensory amplitudes in median nerve conduction study, compared to those in ulnar nerve conduction study. Healthy subjects did not show a difference between median and ulnar nerve conduction studies. The patients with ALS showed delayed latencies and amplitudes of median nerve CMAP, regardless of the presence of peripheral neuropathies. Conclusion: The selective thenar atrophy in ALS is prominently due to the pathophysiological disease progression, regardless of the presence of concomitant peripheral neuropathies. KCI Citation Count: 0