성장호르몬 치료 환아에서 발생한 대퇴골두골단분리증 2례

• Published in: Annals of pediatric endocrinology & metabolism pp. 163 - 167
• Main Authors: 이환석, 홍은희, 조민현, 양은애, 고철우
• Format: Journal Article
• Language: Korean
• Published: 대한소아내분비학회 01.12.2009
• Subjects: 소아과학
• ISSN: 2287-1012; 2287-1292

대퇴골두골단분리증은 주로 청소년기에 발병하는 드문 질환으로 비만, 외상, 성발육 지연, 골성숙 지연, 내분비 질환, 만성 신부전, 유전자 질환, 성장호르몬 치료 그리고 GnRH agonist치료 등과 관련이 있는 것으로 알려져 있다. 이에 저자들은 성장호르몬 치료를 받은 환아 중 2례의 대퇴골두골단분리증을 경험하였기에 문헌 고찰과 함께 보고하는 바이다. Slipped capital femoral epiphysis is a rare hip disorder that mainly occurs in pubertal children. Although the exact cause of this disorder is unknown, it is known to be associated with obesity, trauma, delayed sexual development, delayed bone maturation, chronic renal failure, genetic diseases, endocrine disorders (growth hormone deficiency, hypothyroidism, hypogonadism), growth hormone therapy, and gonadotropin releasing hormone agonist (GnRH agonist) therapy. We report 2 cases of slipped capital femoral epiphysis in adolescent females who were receiving growth hormone therapy. The first case is of a 16 year-old-girl with chronic renal failure and renal osteodystrophy. The second case is of an 11 year-old-girl with idiopathic precocious puberty who had received GnRH agonist and growth hormone therapy. Unilateral or bilateral slipped capital femoral epiphysis developed at 1 year 3 months after treatment in both the cases. The chief complaints were pain in the hip joint and lower extremities. Growth hormone and/or GnRH agonist therapy was stopped, and in situ screw fixations of the involved hip epiphyses were performed. KCI Citation Count: 1