Association of common promoter polymorphisms of MCP1 withhepatitis B virus clearance

• Published in: Experimental & molecular medicine pp. 694 - 702
• Main Authors: 박병래, Yoon Jun Kim, Hyun Sub Cheong, 김영효, Yoo Hyun Choi, Hyo-Suk Lee, 신형두
• Format: Journal Article
• Language: English
• Published: 생화학분자생물학회 01.12.2006
• Subjects: 생화학
• ISSN: 1226-3613; 2092-6413

Hepatocellular carcinoma (HCC) is one of the most common malignant cancers closely associated with chronic infection by the hepatis B virus (HBV) or the hepatitis C virus (HCV) throughout the world. In this study, the genetic associations of 20 known polymorphisms in eight candidate genes, including AGT), cadherin 1 (CDH1), cyclooxy-genase 2 (COX2), monocyte chemotactic protein-1 (MCP1), multidrug resistance 1 (MDR1), chemokine ligand 5 (RANTES), thrombospondin 2 (THBS2), and thrombospondin 4 (THBS4), were analyzed in a large chronic hepatitis B cohort (n=1,095) recruited from the Korean population. In addition, three polymor-phisms in chemokine receptor 4 (CXCR4) and vimentin (VIM) identified in this study were also genotyped. Using logistic regression analysis con-trolling possible confounding factors, one common (freq.=0.367) promoter polymorphism of MCP1 (MCP1-2518G>A) among analyzed polymorphisms was significantly associated with clearance of HBV infection. The frequency of homozygotes for the MCP1-2518A alle ( MCP1-2518A/A) among chronic hepatitis B virus (HBV) carrier patients was sig-nificantly higher than that among spontaneously recovered (SR) subjects (17.7% vs. 10.4%)(OR=1.78, P=0.004). Our findings imply a plausible explanation for the contribution of host genetic determinants to the variable outcome of HBV infection, which might provide valuable information for future genetic study in this area. KCI Citation Count: 29