The effect of folic acid administration on cardiac tissue matrix metalloproteinase activity and hepatorenal biomarkers in diabetic rats1
Diabetes mellitus (DM) is a metabolic disorder that causes severe complications. Thus, the aims of this study were to investigate the influence of DM and folic acid treatment on liver and renal biomarkers, and heart remodeling through evaluation of cardiac matrix metalloproteinase (MMP) activity. Th...
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Published in | Canadian journal of physiology and pharmacology Vol. 97; no. 9; pp. 893 - 901 |
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Main Authors | , , , , , |
Format | Journal Article |
Language | English |
Published |
NRC Research Press
2019
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Abstract | Diabetes mellitus (DM) is a metabolic disorder that causes severe complications. Thus, the aims of this study were to investigate the influence of DM and folic acid treatment on liver and renal biomarkers, and heart remodeling through evaluation of cardiac matrix metalloproteinase (MMP) activity. There were 4 groups: control (physiological saline 1 mL/kg, i.p., 28 days), DM (streptozotocin [STZ] 100 mg/kg in physiological saline, i.p., 1 day), folic acid (FA; 5 mg/kg, i.p., 28 days), and DM+FA (STZ 100 mg/kg, i.p., 1 day and folic acid 5 mg/kg, i.p., 28 days). Our results demonstrated increased aminotransferase and alkaline phosphatase activity, urea and creatinine concentration, and decreased albumin and fibrinogen concentration in the DM group. MMP-2 relative activity was elevated in the DM and FA groups; MMP-9 was decreased in the DM and increased in the FA group. The folic acid treatment of diabetic rats did not change aminotransferase activity; it alleviated the increase in alkaline phosphatase and the decrease in albumin and fibrinogen concentration, and reduced MMP-2 activity; however, it increased urea and creatinine concentration. In conclusion, folic acid treatment of diabetic rats has cardio- and hepato-protective effects. However, its dosing should be carefully considered because of possible renal damage. |
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AbstractList | Diabetes mellitus (DM) is a metabolic disorder that causes severe complications. Thus, the aims of this study were to investigate the influence of DM and folic acid treatment on liver and renal biomarkers, and heart remodeling through evaluation of cardiac matrix metalloproteinase (MMP) activity. There were 4 groups: control (physiological saline 1 mL/kg, i.p., 28 days), DM (streptozotocin [STZ] 100 mg/kg in physiological saline, i.p., 1 day), folic acid (FA; 5 mg/kg, i.p., 28 days), and DM+FA (STZ 100 mg/kg, i.p., 1 day and folic acid 5 mg/kg, i.p., 28 days). Our results demonstrated increased aminotransferase and alkaline phosphatase activity, urea and creatinine concentration, and decreased albumin and fibrinogen concentration in the DM group. MMP-2 relative activity was elevated in the DM and FA groups; MMP-9 was decreased in the DM and increased in the FA group. The folic acid treatment of diabetic rats did not change aminotransferase activity; it alleviated the increase in alkaline phosphatase and the decrease in albumin and fibrinogen concentration, and reduced MMP-2 activity; however, it increased urea and creatinine concentration. In conclusion, folic acid treatment of diabetic rats has cardio- and hepato-protective effects. However, its dosing should be carefully considered because of possible renal damage. |
Abstract_FL | Le diabète sucré (DS) est une maladie métabolique qui cause des complications graves. Par conséquent, ces travaux avaient pour but d’étudier l’influence du DS et de l’administration d’acide folique (AF) sur les biomarqueurs hépatiques et rénaux, ainsi que sur le remodelage du cœur à l’aide de l’évaluation de l’activité des métalloprotéinases matricielles cardiaques. Nous avons formé 4 groupes : témoin (solution physiologique à 1 ml/kg, i.p. pendant 28 jours), DS (streptozotocine [STZ] à 100 mg/kg dans une solution physiologique, i.p. pendant 1 jour), AF (à 5 mg/kg dans une solution physiologique, i.p. pendant 28 jours) et DS + AF (STZ à 100 mg/kg dans une solution physiologique, i.p. pendant 1 jour et AF à 5 mg/kg dans une solution physiologique, i.p. pendant 28 jours). Nos résultats ont montré une hausse de l’activité des aminotransférases et de la phosphatase alcaline, des concentrations d’urée et de créatinine, ainsi qu’un abaissement des concentrations d’albumine et de fibrinogène dans le groupe DS. Nous avons observé une hausse de l’activité relative de la MMP-2 dans les groupes DS et AF, ainsi qu’un abaissement de la MMP-9 dans le groupe DS, mais une hausse dans le groupe AF. L’administration AF n’a pas entraîné de modification de l’activité des aminotransférases chez les rats diabétiques : il entraînait une atténuation de la hausse de la phosphatase alcaline, ainsi qu’un abaissement des concentrations d’albumine et de fibrinogène, avec une diminution de l’activité de la MMP-2; il entraînait toutefois une hausse des concentrations d’urée et de créatinine. En conclusion, l’administration AF permet d’obtenir des effets cardio- et hépatoprotecteurs chez des rats diabétiques. Cependant, il faudrait entreprendre une augmentation des doses AF avec prudence en raison de la possibilité d’observer des lésions rénales. [Traduit par la Rédaction] |
Author | Djuric, Dragan Jakovljevic Uzelac, Jovana Stankovic, Sanja Labudovic Borovic, Milica Gopcevic, Kristina Mutavdzin, Slavica |
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SubjectTerms | cardiac remodelling diabetes mellitus diabète sucré dommages hépatiques dommages rénaux hepatic damage matrix metalloproteinases métalloprotéinases matricielles rat remodelage cardiaque renal damage |
Title | The effect of folic acid administration on cardiac tissue matrix metalloproteinase activity and hepatorenal biomarkers in diabetic rats1 |
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