12. Essential roles of glutamate transporters in excitatory synapses in cerebellar Purkinje cells

We investigated effects of dl-threo-β-benzyloxyasparpostsynaptic currents (EPSCs) in cerebellar Purkinje cells. TBOA markedly prolonged AMPA receptor-mediated EPSCs and generated a continuous inward current in Purkinje cells. The late component of the prolonged EPSC was preferentially inhibited by a...

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Published inTHE KITAKANTO MEDICAL JOURNAL Vol. 54; no. 3; pp. 282 - 283
Main Authors 高安幸弘, 古屋信彦, 小澤瀞司
Format Journal Article
LanguageJapanese
Published The Kitakanto Medical Society 2004
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Summary:We investigated effects of dl-threo-β-benzyloxyasparpostsynaptic currents (EPSCs) in cerebellar Purkinje cells. TBOA markedly prolonged AMPA receptor-mediated EPSCs and generated a continuous inward current in Purkinje cells. The late component of the prolonged EPSC was preferentially inhibited by a low affinity competitive antagonist of AMPA receptors, suggesting that TBOA prolongs the stay of synaptically released glutamate and induces glutamate spillover to neighboring synapses. The continuous inward current was abolished by a blocker of AMPA receptor, indicating that the strong inhibition of glutamate uptake causes the accumulation of glutamate in the extracellular space.
ISSN:1343-2826