Sulfhydryl reagents trigger noradrenaline release from rat brain slices

• Published in: Japanese Journal of Pharmacology Vol. 76; no. suppl.2; p. 254
• Main Authors: Mutsuko Maekawa, Souichi Satoh, Toshihiko Murayama, Yasuyuki Nomura
• Format: Journal Article
• Language: Japanese
• Published: The Japanese Pharmacological Society 1998

Heavy metals like Hg^2+ , Ag^+ , Cu^2+ and Zn^2+ were shown to induce Ca^2+ release from sarcoplasmic reticulum (SR) vesicles by binding to an accessible free sulfhydryl (SH) on a protein. However, the effects of metals on neuronal cells have not been well established. We found that HgCl_2 (200 μM),...