Effect of T-588, a novel cognitive enhancer, on NGF-induced neurite outgrowth in PC12 cells

• Published in: Japanese Journal of Pharmacology Vol. 73; no. suppl.2; p. 280
• Main Authors: Hidetoshi Yamaguchi, Satoshi Ono, Kazunari Hirata, Hirokazu Narita
• Format: Journal Article
• Language: Japanese
• Published: The Japanese Pharmacological Society 1997

We have previously demonstrated that T-588 improved the learning and memory deficits in animal amnesia models, and stimulated phosphoinositide hydrolysis and cAMP formation in rat cortical and hippocampal slices. It is well known that NGF is involved in cell survival and rearrangement of neural netw...