Trypanosoma cruzi Dysregulates piRNAs Computationally Predicted to Target IL-6 Signaling Molecules During Early Infection of Primary Human Cardiac Fibroblasts

• Published in: Immune network Vol. 22; no. 6; pp. 51.1 - 51.20
• Main Authors: Ayorinde Cooley, Kayla J. Rayford, Ashutosh Arun, Fernando Villalta, Maria F. Lima, Siddharth Pratap, Pius N. Nde
• Format: Journal Article
• Language: Korean
• Published: 2022
• Subjects: RNA, small untranslated; Parasites; RNA, small interfering; Immunity; Trypanosoma cruzi; Interleukin-6

Trypanosoma cruzi, the etiological agent of Chagas disease, is an intracellular protozoan parasite, which is now present in most industrialized countries. About 40% of T. cruzi infected individuals will develop severe, incurable cardiovascular, gastrointestinal, or neurological disorders. The molecu...