The RUNX1 Enhancer Element eR1: A Versatile Marker for Adult Stem Cells
The identification of adult stem cells is challenging because of the heterogeneity and plasticity of stem cells in different organs. Within the same tissue, stem cells may be highly proliferative, or maintained in a quiescent state and only to be activated after tissue damage. Although various stem...
Saved in:
Published in | Molecules and cells Vol. 43; no. 2; pp. 121 - 125 |
---|---|
Main Authors | , , |
Format | Journal Article |
Language | Korean |
Published |
2020
|
Subjects | |
Online Access | Get full text |
Cover
Loading…
Abstract | The identification of adult stem cells is challenging because of the heterogeneity and plasticity of stem cells in different organs. Within the same tissue, stem cells may be highly proliferative, or maintained in a quiescent state and only to be activated after tissue damage. Although various stem cell markers have been successfully identified, there is no universal stem cell marker, which is exclusively expressed in all stem cells. Here, we discuss the roles of master developmental regulator RUNX1 in stem cells and the development of a 270 base pair fragment of the Runx1 enhancer (eR1) for use as stem cell marker. Using eR1 to identify stem cells offers a distinct advantage over gene promoters, which might not be expressed exclusively in stem cells. Moreover, RUNX1 has been strongly implicated in various cancer types, such as leukemia, breast, esophageal, prostate, oral, skin, and ovarian cancers-it has been suggested that RUNX1 dysfunction promotes stem cell dysfunction and proliferation. As tissue stem cells are potential candidates for cancer cells-of-origin and cancer stem cells, we will also discuss the use of eR1 to target oncogenic gene manipulations in stem cells and to track subsequent neoplastic changes. |
---|---|
AbstractList | The identification of adult stem cells is challenging because of the heterogeneity and plasticity of stem cells in different organs. Within the same tissue, stem cells may be highly proliferative, or maintained in a quiescent state and only to be activated after tissue damage. Although various stem cell markers have been successfully identified, there is no universal stem cell marker, which is exclusively expressed in all stem cells. Here, we discuss the roles of master developmental regulator RUNX1 in stem cells and the development of a 270 base pair fragment of the Runx1 enhancer (eR1) for use as stem cell marker. Using eR1 to identify stem cells offers a distinct advantage over gene promoters, which might not be expressed exclusively in stem cells. Moreover, RUNX1 has been strongly implicated in various cancer types, such as leukemia, breast, esophageal, prostate, oral, skin, and ovarian cancers-it has been suggested that RUNX1 dysfunction promotes stem cell dysfunction and proliferation. As tissue stem cells are potential candidates for cancer cells-of-origin and cancer stem cells, we will also discuss the use of eR1 to target oncogenic gene manipulations in stem cells and to track subsequent neoplastic changes. |
Author | Chuang, Linda Shyue Huey Osato, Motomi Ito, Yoshiaki |
Author_xml | – sequence: 1 fullname: Chuang, Linda Shyue Huey – sequence: 2 fullname: Osato, Motomi – sequence: 3 fullname: Ito, Yoshiaki |
BookMark | eNqNysEKgkAUQNEhDLLyH96mpTBvtNHaSVhRVGAW7cTyRUPTCM70_7XoA1rdxblD5pnWUI_5XOAsRB4Jj_nIUYZpnKQDFlirrjyecS5FlPpsVT4IitP-gpCbR21u1EGu6UXGARU4hwzO1NnaKU2wq7vn1-9tB1nz1g6Ojl6wIK3tmPXvtbYU_Dpik2VeLtbhU1mnKtNYXW2y7UFwwTHGKSZSJDKO_v0-QOI7Fw |
ContentType | Journal Article |
DBID | JDI |
DEWEY | 570 |
DatabaseName | KoreaScience |
DatabaseTitleList | |
DeliveryMethod | fulltext_linktorsrc |
Discipline | Biology |
DocumentTitleAlternate | The RUNX1 Enhancer Element eR1: A Versatile Marker for Adult Stem Cells |
EISSN | 0219-1032 |
EndPage | 125 |
ExternalDocumentID | JAKO202014151762764 |
GroupedDBID | --- .UV 0VY 123 1N0 29M 2VQ 2WC 30V 3V. 4.4 408 40D 53G 5VS 67N 67Z 7X7 88A 88E 8AO 8FE 8FH 8FI 8FJ 8TC 8UJ 95. 9ZL AARHV ABDBF ABJNI ABMNI ABTEG ABUWG ACBXY ACGFO ACGFS ACPRK ACREN ADBBV ADINQ ADKPE AENEX AFGCZ AFKRA AFLOW AFNRJ AGJBK AHBYD AHMBA AHSBF ALMA_UNASSIGNED_HOLDINGS AMKLP AMTXH AOIJS ASPBG AVWKF AZFZN BBNVY BENPR BGNMA BHPHI BPHCQ BVBZV BVXVI CAG CCPQU COF CS3 CSCUP DU5 E3Z EAD EAP EBC EBD EBS EJD EMK EMOBN EST ESX F5P FDB FYUFA GX1 HCIFZ HF~ HG6 HH5 HMCUK HMJXF HYE HZ~ I09 I0C IXC I~X JDI KDC KOV KVFHK LAS LK8 M0L M1P M41 M4Y M7P MA- NU0 OK1 P2P PQQKQ PROAC PSQYO Q2X R9I ROL RPM RSV S1Z S27 S3A S3B SBL SDH SJN SOJ SV3 T13 TSK TUS U2A UKHRP VC2 WK8 Z45 ~A9 |
ID | FETCH-kisti_ndsl_JAKO2020141517627643 |
ISSN | 1016-8478 |
IngestDate | Mon Jan 29 07:33:21 EST 2024 |
IsOpenAccess | true |
IsPeerReviewed | true |
IsScholarly | true |
Issue | 2 |
Keywords | stem cells enhancer eR1 RUNX1 |
Language | Korean |
LinkModel | OpenURL |
MergedId | FETCHMERGED-kisti_ndsl_JAKO2020141517627643 |
Notes | KISTI1.1003/JNL.JAKO202014151762764 |
OpenAccessLink | http://click.ndsl.kr/servlet/LinkingDetailView?cn=JAKO202014151762764&dbt=JAKO&org_code=O481&site_code=SS1481&service_code=01 |
ParticipantIDs | kisti_ndsl_JAKO202014151762764 |
PublicationCentury | 2000 |
PublicationDate | 2020 |
PublicationDateYYYYMMDD | 2020-01-01 |
PublicationDate_xml | – year: 2020 text: 2020 |
PublicationDecade | 2020 |
PublicationTitle | Molecules and cells |
PublicationTitleAlternate | Molecules and cells |
PublicationYear | 2020 |
SSID | ssib049006238 ssj0017628 ssib053376808 |
Score | 4.4849334 |
Snippet | The identification of adult stem cells is challenging because of the heterogeneity and plasticity of stem cells in different organs. Within the same tissue,... |
SourceID | kisti |
SourceType | Open Access Repository |
StartPage | 121 |
Title | The RUNX1 Enhancer Element eR1: A Versatile Marker for Adult Stem Cells |
URI | http://click.ndsl.kr/servlet/LinkingDetailView?cn=JAKO202014151762764&dbt=JAKO&org_code=O481&site_code=SS1481&service_code=01 |
Volume | 43 |
hasFullText | 1 |
inHoldings | 1 |
isFullTextHit | |
isPrint | |
link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1Ja8JAFB5KodBL6UpXmUN7ClOyaGJ6C2IrFhWsgj2JMROUxgQ0Huyv73vzYkyLdLuEMJmsX_LNNy9vYey24gS6VQ5tUXXNQMCX6Iuq5ftiZIW6NbJ1KZXzeKttN_rl5qAy2FSmU9ElqX8_ft8aV_IfVKENcMUo2T8gmx8UGmAd8IUlIAzLX2Pc7bcHhlaPJwjfXKuTO7gmuwYFnaNBDLpHUoXlQA_0K_Qw6wZ6eM20moyiRVGitqhgrqTkzeN8M5WOyszLaiqvvUxWS6k1ljK3y3fgXMr42krSZDbNXzxqfE0WkylI1qKpwdQLvAjKUMBARlQpiZ-A7ATm4yuSKeVcyl4as8CMBgVCZ4OsQdHOn_NffxmXcm_BpvfcwcsxQGwYQN6OjflfYeKLtRL6prfmj7KLEaEbPgEl62BlkfyvEuxLoZHZzcCEBFX6tKAoeofsIJsKcI9wPWI7b8kx26PioKsT9gTocoUuX6PLM3Q5oPvAPZ5jywlbDthyhS1HbLnC9pTdPdZ7tYZQFzGMg0U03HKv1hnbjZNYnjMeGD7wsXTlKHRBx0rXDQNn7Jum44Qg7MwLVvr-WJc_dbhi-9hCRqZrtpvOl_IGZFfql9Sz_gDlnCnr |
link.rule.ids | 230,314,780,784,885,4024 |
linkProvider | Springer Nature |
openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=The+RUNX1+Enhancer+Element+eR1%3A+A+Versatile+Marker+for+Adult+Stem+Cells&rft.jtitle=Molecules+and+cells&rft.au=Chuang%2C+Linda+Shyue+Huey&rft.au=Osato%2C+Motomi&rft.au=Ito%2C+Yoshiaki&rft.date=2020&rft.issn=1016-8478&rft.eissn=0219-1032&rft.volume=43&rft.issue=2&rft.spage=121&rft.epage=125&rft.externalDBID=n%2Fa&rft.externalDocID=JAKO202014151762764 |
thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=1016-8478&client=summon |
thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=1016-8478&client=summon |
thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=1016-8478&client=summon |