Up-Regulation of RANK Expression via ERK1/2 by Insulin Contributes to the Enhancement of Osteoclast Differentiation

• Published in: Molecules and cells Vol. 40; no. 5; pp. 371 - 377
• Main Authors: Oh, Ju Hee, Lee, Na Kyung
• Format: Journal Article
• Language: Korean
• Published: 2017
• Subjects: ERK1/2; insulin; RANK; osteoclastogenesis

Despite the importance of the receptor activator of nuclear factor (NF)-kappaB ligand (RANKL)-RANK signaling mechanisms on osteoclast differentiation, little has been studied on how RANK expression is regulated or what regulates its expression during osteoclastogenesis. We show here that insulin sig...