Cellular Dynamics of Rad51 and Rad54 in Response to Postreplicative Stress and DNA Damage in HeLa Cells

• Published in: Molecules and cells Vol. 40; no. 2; pp. 143 - 150
• Main Authors: Choi, Eui-Hwan, Yoon, Seobin, Hahn, Yoonsoo, Kim, Keun P
• Format: Journal Article
• Language: Korean
• Published: 2017
• Subjects: Rad51; homologous recombination; Rad54; DNA damage; HeLa cell

Homologous recombination (HR) is necessary for maintenance of genomic integrity and prevention of various mutations in tumor suppressor genes and proto-oncogenes. Rad51 and Rad54 are key HR factors that cope with replication stress and DNA breaks in eukaryotes. Rad51 binds to single-stranded DNA (ss...