Nedaplatin Salvage Chemotherapy for Cervical Cancer

Purpose: This systematic analysis was conducted to evaluate the efficacy and safety of nedaplatin based salvage chemotherapy for treatment of patients with advanced cervical cancer. Methods: Clinical studies evaluating the efficacy and safety of nedaplatin based regimens on response and safety for p...

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Published inAsian Pacific journal of cancer prevention : APJCP Vol. 16; no. 8; pp. 3159 - 3162
Main Authors Li, Wu-Ju, Jiang, Jia-ying, Wang, Xian-Lian
Format Journal Article
LanguageKorean
Published 2015
Subjects
nedaplatin
response rate
Cervical cancer
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Summary:Purpose: This systematic analysis was conducted to evaluate the efficacy and safety of nedaplatin based salvage chemotherapy for treatment of patients with advanced cervical cancer. Methods: Clinical studies evaluating the efficacy and safety of nedaplatin based regimens on response and safety for patients with cervical cancer were identified using a predefined search strategy. Pooled response rates (RRs) were calculated. Results: For nedaplatin based regimens, 5 clinical studies including 264 patients with advanced cervical cancer were considered eligible for inclusion. The analysis showed that, in all patients, pooled RR was 74.6% (197/264). Major adverse effects were leukopenia, thrombocytopenia and nausea/vomiting. No treatment related death occurred with nedaplatin based treatment. Conclusion: This systematic analysis suggests that nedaplatin based regimens are associated with good activity with acceptable tolerability in treating patients with advanced cervical cancer.
Bibliography:KISTI1.1003/JNL.JAKO201528551641002
ISSN:1513-7368
2476-762X