Lack of Prognostic Significance of SOCS-1 Expression in Colorectal Adenocarcinomas

• Published in: Asian Pacific journal of cancer prevention : APJCP Vol. 15; no. 19; pp. 8469 - 8474
• Main Authors: Ayyildiz, Talat, Dolar, Enver, Adim, Saduman Balaban, Eminler, Ahmet Tarik, Yerci, Omer
• Format: Journal Article
• Language: Korean
• Published: 2014
• Subjects: suppressor of cytokine signaling-1; tumour suppressor; Colorectal carcinoma; methylation
• ISSN: 1513-7368; 2476-762X

Introduction: Recent studies have indicated that down-regulation of the suppressor of cytokine signaling-1 (SOCS-1) gene results in tumor formation and that SOCS-1 acts as a tumor suppressor gene. SOCS-1 has been also suggested to function as a tumor suppressor with colorectal cancer. Objectives: In the present study, we aimed to determine the association of SOCS-1 expression in colorectal cancer tissues with clinicopathologic characteristics immunohistochemically and also to identify its prognostic significance. Materials and Methods: SOCS-1 expression was studied immunohistochemically in 67 patients diagnosed with resected colorectal carcinomas and 30 control subjects. Results: SOCS-1 expression was found in 46.3% of tumor tissues and 46.7% of the control group. Statistical analyses did not establish any significant association between SOCS-1 expression and clinicopathologic characteristics. Also, no significant association with SOCS-1 expression was found using progression-free survival and overall survival analyses (p=0.326 and p=0.360, respectively). Conclusions: Our results show that SOCS-1 has no prognostic significance in colorectal cancer.