TRAIL Mediated Signaling in Pancreatic Cancer
Research over the years has progressively shown substantial broadening of the tumor necrosis factor alpha-related apoptosis-inducing ligand (TRAIL)-mediated signaling landscape. Increasingly it is being realized that pancreatic cancer is a multifaceted and genomically complex disease. Suppression of...
Saved in:
Published in | Asian Pacific journal of cancer prevention : APJCP Vol. 15; no. 15; pp. 5977 - 5982 |
---|---|
Main Authors | , , , , , , |
Format | Journal Article |
Language | Korean |
Published |
2014
|
Subjects | |
Online Access | Get full text |
Cover
Loading…
Abstract | Research over the years has progressively shown substantial broadening of the tumor necrosis factor alpha-related apoptosis-inducing ligand (TRAIL)-mediated signaling landscape. Increasingly it is being realized that pancreatic cancer is a multifaceted and genomically complex disease. Suppression of tumor suppressors, overexpression of oncogenes, epigenetic silencing, and loss of apoptosis are some of the extensively studied underlying mechanisms. Rapidly accumulating in vitro and in vivo evidence has started to shed light on the resistance mechanisms in pancreatic cancer cells. More interestingly a recent research has opened new horizons of miRNA regulation by DR5 in pancreatic cancer cells. It has been shown that DR5 interacts with the core microprocessor components Drosha and DGCR8, thus impairing processing of primary let-7. Xenografting DR5 silenced pancreatic cancer cells in SCID-mice indicated that there was notable suppression of tumor growth. There is a paradigm shift in our current understanding of TRAIL mediated signaling in pancreatic cancer cells that is now adding new layers of concepts into the existing scientific evidence. In this review we have attempted to provide an overview of recent advances in TRAIL mediated signaling in pancreatic cancer as evidenced by findings of in vitro and in vivo analyses. Furthermore, we discuss nanotechnological advances with emphasis on PEG-TRAIL and four-arm PEG cross-linked hyaluronic acid (HA) hydrogels to improve availability of TRAIL at target sites. |
---|---|
AbstractList | Research over the years has progressively shown substantial broadening of the tumor necrosis factor alpha-related apoptosis-inducing ligand (TRAIL)-mediated signaling landscape. Increasingly it is being realized that pancreatic cancer is a multifaceted and genomically complex disease. Suppression of tumor suppressors, overexpression of oncogenes, epigenetic silencing, and loss of apoptosis are some of the extensively studied underlying mechanisms. Rapidly accumulating in vitro and in vivo evidence has started to shed light on the resistance mechanisms in pancreatic cancer cells. More interestingly a recent research has opened new horizons of miRNA regulation by DR5 in pancreatic cancer cells. It has been shown that DR5 interacts with the core microprocessor components Drosha and DGCR8, thus impairing processing of primary let-7. Xenografting DR5 silenced pancreatic cancer cells in SCID-mice indicated that there was notable suppression of tumor growth. There is a paradigm shift in our current understanding of TRAIL mediated signaling in pancreatic cancer cells that is now adding new layers of concepts into the existing scientific evidence. In this review we have attempted to provide an overview of recent advances in TRAIL mediated signaling in pancreatic cancer as evidenced by findings of in vitro and in vivo analyses. Furthermore, we discuss nanotechnological advances with emphasis on PEG-TRAIL and four-arm PEG cross-linked hyaluronic acid (HA) hydrogels to improve availability of TRAIL at target sites. |
Author | Naqvi, Syed Kamran-Ul-Hassan Aamir, Qurratulain Kahraman, OzlemTimirci Yaylim, Ilhan Farooqi, Ammad Ahmad Nogueira, Daniele Rubert Fayyaz, Sundas |
Author_xml | – sequence: 1 fullname: Nogueira, Daniele Rubert – sequence: 2 fullname: Yaylim, Ilhan – sequence: 3 fullname: Aamir, Qurratulain – sequence: 4 fullname: Kahraman, OzlemTimirci – sequence: 5 fullname: Fayyaz, Sundas – sequence: 6 fullname: Naqvi, Syed Kamran-Ul-Hassan – sequence: 7 fullname: Farooqi, Ammad Ahmad |
BookMark | eNqNyrsKwjAUgOGDVLBq3yGLY6C5NNGxFMUrinZwK7GN5WA5QtP3RwcfwOn_hn8KEb3JjyCW2hpujbxHEItMKG6VWU4gCQEfqdZWpUbrGHh5zXdHdvINusE37IYtuQ6pZUjs4qjuvRuwZsWXvp_D-Om64JNfZ7DYrMtiy18YBqyoCV21zw9nmQotV9ZkwlihhPr3-wBkEzMG |
ContentType | Journal Article |
DBID | JDI |
DEWEY | 616.994 |
DatabaseName | KoreaScience |
DatabaseTitleList | |
DeliveryMethod | fulltext_linktorsrc |
Discipline | Medicine |
DocumentTitleAlternate | TRAIL Mediated Signaling in Pancreatic Cancer |
EISSN | 2476-762X |
EndPage | 5982 |
ExternalDocumentID | JAKO201429765167131 |
GroupedDBID | --- .UV 23N 2WC 53G 5GY 9ZL ADBBV ALMA_UNASSIGNED_HOLDINGS AOIJS BAWUL BCNDV C1A DIK E3Z EBS EJD F5P FRJ GROUPED_DOAJ GX1 HYE JDI OK1 RPM TR2 W2D WOW |
ID | FETCH-kisti_ndsl_JAKO2014297651671313 |
ISSN | 1513-7368 |
IngestDate | Fri Dec 22 12:04:04 EST 2023 |
IsOpenAccess | true |
IsPeerReviewed | true |
IsScholarly | true |
Issue | 15 |
Keywords | TRAIL Pancreatic cancer nanotechnology apoptosis |
Language | Korean |
LinkModel | OpenURL |
MergedId | FETCHMERGED-kisti_ndsl_JAKO2014297651671313 |
Notes | KISTI1.1003/JNL.JAKO201429765167131 |
OpenAccessLink | http://click.ndsl.kr/servlet/LinkingDetailView?cn=JAKO201429765167131&dbt=JAKO&org_code=O481&site_code=SS1481&service_code=01 |
ParticipantIDs | kisti_ndsl_JAKO201429765167131 |
PublicationCentury | 2000 |
PublicationDate | 2014 |
PublicationDateYYYYMMDD | 2014-01-01 |
PublicationDate_xml | – year: 2014 text: 2014 |
PublicationDecade | 2010 |
PublicationTitle | Asian Pacific journal of cancer prevention : APJCP |
PublicationTitleAlternate | Asian Pacific journal of cancer prevention : APJCP |
PublicationYear | 2014 |
SSID | ssib044730644 ssib007832521 ssj0045875 |
Score | 4.03601 |
Snippet | Research over the years has progressively shown substantial broadening of the tumor necrosis factor alpha-related apoptosis-inducing ligand (TRAIL)-mediated... |
SourceID | kisti |
SourceType | Open Access Repository |
StartPage | 5977 |
Title | TRAIL Mediated Signaling in Pancreatic Cancer |
URI | http://click.ndsl.kr/servlet/LinkingDetailView?cn=JAKO201429765167131&dbt=JAKO&org_code=O481&site_code=SS1481&service_code=01 |
Volume | 15 |
hasFullText | 1 |
inHoldings | 1 |
isFullTextHit | |
isPrint | |
link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1JS8NAFB6kB_EirriWHPRUUrJMtmMoSlvtYqnQW5kkUzuYphDbg_31vplsoxS3SwhDyPY-3vvey_teELqZUWp5kW2p1NUiFUcYq0SHnMf2DB5dtJAKuVivb7efcXdiTao-XaEuWQXNcLNVV_Ifq8Ia2JWrZP9g2fKksAD7YF_YgoVh-zsbj_zOo_jWQgRxZC-cVmcilSGYUxDCsNHilk1lGuoL6WTekCdPjwjFoXxyQNEHKSqHw26r1IH1ebGHpUQSqDdGa96fXXoQ8h5nP2nuxPMKfT5ZMIGPp3XKJznHhFUtAGSekrwYO9jEdAEYYmnI5KJEJgMtPKhuqo6Z_SunScWagR1bBa87-eR2LRleluRE-Ug8KSDzEYNVtCq-0H8JYmVrYdd_GPA7MoBnWboNObgYbaBhOd_mzsYBXyZxF4wdnozhIoxjyxVTmsvngeyFU3om0Y_xAdrP8wbFz0BwiHZel0dot5d3RhwjVWBBKbCglFhQWKJUWFAyLJyg2_u7cautimtNk-gtnm55JPMU1ZJlQs-QgilQwhn1iK6F2DawGwSuQ70Z8ajphK5zjurfn-vipwMu0R5fyQpPV6i2Stf0GqjYKqiLV_oBAQUzBQ |
link.rule.ids | 230,315,786,790,891,4043 |
linkProvider | Directory of Open Access Journals |
openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=TRAIL+Mediated+Signaling+in+Pancreatic+Cancer&rft.jtitle=Asian+Pacific+journal+of+cancer+prevention+%3A+APJCP&rft.au=Nogueira%2C+Daniele+Rubert&rft.au=Yaylim%2C+Ilhan&rft.au=Aamir%2C+Qurratulain&rft.au=Kahraman%2C+OzlemTimirci&rft.date=2014&rft.issn=1513-7368&rft.eissn=2476-762X&rft.volume=15&rft.issue=15&rft.spage=5977&rft.epage=5982&rft.externalDBID=n%2Fa&rft.externalDocID=JAKO201429765167131 |
thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=1513-7368&client=summon |
thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=1513-7368&client=summon |
thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=1513-7368&client=summon |