Effect of Botulinum Toxin A on Proliferation and Apoptosis in the T47D Breast Cancer Cell Line

The present study was performed to assess the activity of the botulinum toxin A on breast cancer cells. The T47D cell line was exposed to diverse concentrations of the botulinum toxin A and cell viability and apoptosis were estimated using MTT and propidium iodine/annexin V methods, respectively. Bo...

Full description

Saved in:
Bibliographic Details
Published inAsian Pacific journal of cancer prevention : APJCP Vol. 14; no. 2; pp. 891 - 894
Main Authors Bandala, Cindy, Perez-Santos, Jose Luis Martin, Lara-Padilla, Eleazar, Delgado Lopez, Ma. Guadalupe, Anaya-Ruiz, Maricruz
Format Journal Article
LanguageKorean
Published 2013
Subjects
botulinum toxin A
apoptosis
Breast cancer
caspases
Online AccessGet full text

Cover

Abstract The present study was performed to assess the activity of the botulinum toxin A on breast cancer cells. The T47D cell line was exposed to diverse concentrations of the botulinum toxin A and cell viability and apoptosis were estimated using MTT and propidium iodine/annexin V methods, respectively. Botulinum toxin A exerted greater cytotoxic activity in T47D cells in comparison with MCF10A normal cells; this appeared to be via apoptotic processes caspase-3 and -7. In conclusion, botulinum toxin A induces caspase-3 and -7 dependent apoptotic processes in the T47D breast cancer cell line.
AbstractList The present study was performed to assess the activity of the botulinum toxin A on breast cancer cells. The T47D cell line was exposed to diverse concentrations of the botulinum toxin A and cell viability and apoptosis were estimated using MTT and propidium iodine/annexin V methods, respectively. Botulinum toxin A exerted greater cytotoxic activity in T47D cells in comparison with MCF10A normal cells; this appeared to be via apoptotic processes caspase-3 and -7. In conclusion, botulinum toxin A induces caspase-3 and -7 dependent apoptotic processes in the T47D breast cancer cell line.
Author Lara-Padilla, Eleazar
Anaya-Ruiz, Maricruz
Delgado Lopez, Ma. Guadalupe
Bandala, Cindy
Perez-Santos, Jose Luis Martin
Author_xml – sequence: 1
  fullname: Bandala, Cindy
– sequence: 2
  fullname: Perez-Santos, Jose Luis Martin
– sequence: 3
  fullname: Lara-Padilla, Eleazar
– sequence: 4
  fullname: Delgado Lopez, Ma. Guadalupe
– sequence: 5
  fullname: Anaya-Ruiz, Maricruz
BookMark eNqNys1qwkAUQOGhWGisvsPddBnI_CSTbUwVqUK7yKIrw1Tv0EundyQzQh9fFz5AV4cD31zMODI-iEIZ25S2UZ8zUcha6tLqpn0Sy5ToqzLG6qoxphCHtfd4zBA9rGK-BOLLLwzxjxg6iAwfUwzkcXKZbuf4BN05nnNMlOBm8jfCYOwrrCZ0KUPv-IgT9BgC7IlxIR69CwmX9z6Ll8166LflD6VMI59SGN-63buqpFZS1VK2lWxr_V93BZebRDs
ContentType Journal Article
DBID JDI
DEWEY 616.994
DatabaseName KoreaScience
DatabaseTitleList
DeliveryMethod fulltext_linktorsrc
Discipline Medicine
DocumentTitleAlternate Effect of Botulinum Toxin A on Proliferation and Apoptosis in the T47D Breast Cancer Cell Line
EISSN 2476-762X
EndPage 894
ExternalDocumentID JAKO201321251180185
GroupedDBID ---
.UV
23N
2WC
53G
5GY
9ZL
ADBBV
ALMA_UNASSIGNED_HOLDINGS
AOIJS
BAWUL
BCNDV
C1A
DIK
E3Z
EBS
EJD
F5P
FRJ
GROUPED_DOAJ
GX1
HYE
JDI
OK1
RPM
TR2
W2D
WOW
ID FETCH-kisti_ndsl_JAKO2013212511801853
ISSN 1513-7368
IngestDate Fri Dec 22 11:59:06 EST 2023
IsOpenAccess true
IsPeerReviewed true
IsScholarly true
Issue 2
Keywords botulinum toxin A
apoptosis
Breast cancer
caspases
Language Korean
LinkModel OpenURL
MergedId FETCHMERGED-kisti_ndsl_JAKO2013212511801853
Notes KISTI1.1003/JNL.JAKO201321251180185
OpenAccessLink http://click.ndsl.kr/servlet/LinkingDetailView?cn=JAKO201321251180185&dbt=JAKO&org_code=O481&site_code=SS1481&service_code=01
ParticipantIDs kisti_ndsl_JAKO201321251180185
PublicationCentury 2000
PublicationDate 2013
PublicationDateYYYYMMDD 2013-01-01
PublicationDate_xml – year: 2013
  text: 2013
PublicationDecade 2010
PublicationTitle Asian Pacific journal of cancer prevention : APJCP
PublicationTitleAlternate Asian Pacific journal of cancer prevention : APJCP
PublicationYear 2013
SSID ssib044730644
ssib007832521
ssj0045875
Score 3.9690955
Snippet The present study was performed to assess the activity of the botulinum toxin A on breast cancer cells. The T47D cell line was exposed to diverse...
SourceID kisti
SourceType Open Access Repository
StartPage 891
Title Effect of Botulinum Toxin A on Proliferation and Apoptosis in the T47D Breast Cancer Cell Line
URI http://click.ndsl.kr/servlet/LinkingDetailView?cn=JAKO201321251180185&dbt=JAKO&org_code=O481&site_code=SS1481&service_code=01
Volume 14
hasFullText 1
inHoldings 1
isFullTextHit
isPrint
link http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV3Nb9MwFLeqHdAuCNgQMJh8GKfIVZs6dXLsMqaptKMSReqJyXVcNFHiqEsk6J_CX8t7duKl0wRslyiy8uHk99Pze8_vg5ATGUUqSaRiPI4yxlc8YUvVTxgmZYol9o-2eWvTy-HFFz5eRItO53craqkql121vTev5DGowhjgilmyD0DWPxQG4BzwhSMgDMf_wrguPQz63qkpMaS8-hHMzU90YeAmwAw78qx0jTF6yEeFKUqDNUjq8MY5F2eALzbwCVIkwCZI0Zs3abbbmwK1NteyjuBrl5tQ7qairgSFXEJX42yc-sSxU3RWrK2Sml7n2a9babzRW_YZuxj7zYhgUsHkXG0DHyskN5LNZIb9kVwkmpZb6YOKz_T6m8xMMDGF84ZPZReZD--sCt32arh01EYE9wdMDFyzna62YyEXQwZie7Ejt3mLn2FLCMeu_1eznrsmyrultu8sgT4wcTz6-AmnE_at6dUDbQYLI_R421pHUSVAErY0H84FmnK8UQJ4FNsaz_5jwPZBg-C6pbzMn5GntdVBR45Cz0nnu3lBnkzruIoD8tUxiZoV9Uyilkl0RE1Od5hEAU_qmUThGmASRSZRxyTqmESRSRSZdEjen3-YpxfMTu4qz27WV_f8g8FLspebXL8iVCRZEgudSa40lwOVCDlUwzDJejGs4Wr1mhz__Vlv_nXBEdkPbc8R9HO9JXvlptLvQPMrl8cWgz8XTlpW
link.rule.ids 230,315,786,790,891,4043
linkProvider Directory of Open Access Journals
openUrl ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Effect+of+Botulinum+Toxin+A+on+Proliferation+and+Apoptosis+in+the+T47D+Breast+Cancer+Cell+Line&rft.jtitle=Asian+Pacific+journal+of+cancer+prevention+%3A+APJCP&rft.au=Bandala%2C+Cindy&rft.au=Perez-Santos%2C+Jose+Luis+Martin&rft.au=Lara-Padilla%2C+Eleazar&rft.au=Delgado+Lopez%2C+Ma.+Guadalupe&rft.date=2013&rft.issn=1513-7368&rft.eissn=2476-762X&rft.volume=14&rft.issue=2&rft.spage=891&rft.epage=894&rft.externalDBID=n%2Fa&rft.externalDocID=JAKO201321251180185
thumbnail_l http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=1513-7368&client=summon
thumbnail_m http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=1513-7368&client=summon
thumbnail_s http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=1513-7368&client=summon