Effect of Botulinum Toxin A on Proliferation and Apoptosis in the T47D Breast Cancer Cell Line
The present study was performed to assess the activity of the botulinum toxin A on breast cancer cells. The T47D cell line was exposed to diverse concentrations of the botulinum toxin A and cell viability and apoptosis were estimated using MTT and propidium iodine/annexin V methods, respectively. Bo...
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Published in | Asian Pacific journal of cancer prevention : APJCP Vol. 14; no. 2; pp. 891 - 894 |
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Main Authors | , , , , |
Format | Journal Article |
Language | Korean |
Published |
2013
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Subjects | |
Online Access | Get full text |
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Abstract | The present study was performed to assess the activity of the botulinum toxin A on breast cancer cells. The T47D cell line was exposed to diverse concentrations of the botulinum toxin A and cell viability and apoptosis were estimated using MTT and propidium iodine/annexin V methods, respectively. Botulinum toxin A exerted greater cytotoxic activity in T47D cells in comparison with MCF10A normal cells; this appeared to be via apoptotic processes caspase-3 and -7. In conclusion, botulinum toxin A induces caspase-3 and -7 dependent apoptotic processes in the T47D breast cancer cell line. |
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AbstractList | The present study was performed to assess the activity of the botulinum toxin A on breast cancer cells. The T47D cell line was exposed to diverse concentrations of the botulinum toxin A and cell viability and apoptosis were estimated using MTT and propidium iodine/annexin V methods, respectively. Botulinum toxin A exerted greater cytotoxic activity in T47D cells in comparison with MCF10A normal cells; this appeared to be via apoptotic processes caspase-3 and -7. In conclusion, botulinum toxin A induces caspase-3 and -7 dependent apoptotic processes in the T47D breast cancer cell line. |
Author | Lara-Padilla, Eleazar Anaya-Ruiz, Maricruz Delgado Lopez, Ma. Guadalupe Bandala, Cindy Perez-Santos, Jose Luis Martin |
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Keywords | botulinum toxin A apoptosis Breast cancer caspases |
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Title | Effect of Botulinum Toxin A on Proliferation and Apoptosis in the T47D Breast Cancer Cell Line |
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