Genetic Risk Prediction for Normal-Karyotype Acute Myeloid Leukemia Using Whole-Exome Sequencing

• Published in: Genomics & informatics Vol. 11; no. 1; pp. 46 - 51
• Main Authors: Heo, Seong Gu, Hong, Eun Pyo, Park, Ji Wan
• Format: Journal Article
• Language: Korean
• Published: 2013
• Subjects: risk assessment; DNA sequence analysis; acute myeloid leukemia; genetic variation

Normal-karyotype acute myeloid leukemia (NK-AML) is a highly malignant and cytogenetically heterogeneous hematologic cancer. We searched for somatic mutations from 10 pairs of tumor and normal cells by using a highly efficient and reliable analysis workflow for whole-exome sequencing data and perfor...