S-benzyl-cysteine-mediated Cell Cycle Arrest and Apoptosis Involving Activation of Mitochondrial-dependent Caspase Cascade through the p53 Pathway in Human Gastric Cancer SGC-7901 Cells

• Published in: Asian Pacific journal of cancer prevention : APJCP Vol. 14; no. 11; pp. 6379 - 6384
• Main Authors: Sun, Hua-Jun, Meng, Lin-Yi, Shen, Yang, Zhu, Yi-Zhun, Liu, Hong-Rui
• Format: Journal Article
• Language: Korean
• Published: 2013
• Subjects: Aged garlic extract; apoptosis-cell cycle; SGC-7901 cell; p53 signalling pathway

S-benzyl-cysteine (SBC) is a structural analog of S-allylcysteine (SAC), which is one of the major water-soluble compounds in aged garlic extract. In this study, anticancer activities and the underlying mechanisms of SBC action were investigated and compared these with those of SAC using human gastr...