Expression Characteristics of Proteins of the Insulin-like Growth Factor Axis in Non-small Cell Lung Cancer Patients with Preexisting Type 2 Diabetes Mellitus
Background: Preexisting type 2 diabetes mellitus (T2DM) affects the prognosis and mortality of patients with some cancers. Insulin like growth factor (IGF) and insulin receptor (IR) signaling axes play important roles in both cancer and diabetes development. We aimed to explore the expression charac...
Saved in:
Published in | Asian Pacific journal of cancer prevention : APJCP Vol. 14; no. 10; pp. 5675 - 5680 |
---|---|
Main Authors | , , , , , , , , , , , |
Format | Journal Article |
Language | Korean |
Published |
2013
|
Subjects | |
Online Access | Get full text |
Cover
Loading…
Abstract | Background: Preexisting type 2 diabetes mellitus (T2DM) affects the prognosis and mortality of patients with some cancers. Insulin like growth factor (IGF) and insulin receptor (IR) signaling axes play important roles in both cancer and diabetes development. We aimed to explore the expression characteristics of proteins in IGF/IR axis in non-small cell lung cancer (NSCLC) cases with preexisting T2DM. Methods: Fifty-five NSCLC patients with preexisting T2DM were retrospectively included and matched by 55 NSCLC without diabetes at a 1:1 ratio. The expression of proteins in IGF/IR axis was detected by immunohistochemical staining. Clinicopathological data were collected to analyze their relationship with the protein expression. Results: Both IGF 1 receptor (IGF-1R) and insulin receptor substrate 2 (IRS-2) showed higher expression in the NSCLC with T2DM group, compared with those without T2DM. The high expression of IGF-1R and IRS-2 were found to be negatively associated with lymph node metastases and T staging in the T2DM group, respectively, and IRS-2 expression was also found more in the subgroup whose T2DM duration was more than 4 years. No difference was detected in the expression of IRS-1, IGF-1, IGF-2, IGFBP3, IR and mTOR between groups with or without T2DM. Conclusion: Our study found higher expression of IGF-1R and IRS-2 proteins in NSCLC patients with preexisting T2DM, and that there was an association with early stage NSCLC, which suggested that IGF signaling may play an important early event in development of NSCLC associated with diabetes. |
---|---|
AbstractList | Background: Preexisting type 2 diabetes mellitus (T2DM) affects the prognosis and mortality of patients with some cancers. Insulin like growth factor (IGF) and insulin receptor (IR) signaling axes play important roles in both cancer and diabetes development. We aimed to explore the expression characteristics of proteins in IGF/IR axis in non-small cell lung cancer (NSCLC) cases with preexisting T2DM. Methods: Fifty-five NSCLC patients with preexisting T2DM were retrospectively included and matched by 55 NSCLC without diabetes at a 1:1 ratio. The expression of proteins in IGF/IR axis was detected by immunohistochemical staining. Clinicopathological data were collected to analyze their relationship with the protein expression. Results: Both IGF 1 receptor (IGF-1R) and insulin receptor substrate 2 (IRS-2) showed higher expression in the NSCLC with T2DM group, compared with those without T2DM. The high expression of IGF-1R and IRS-2 were found to be negatively associated with lymph node metastases and T staging in the T2DM group, respectively, and IRS-2 expression was also found more in the subgroup whose T2DM duration was more than 4 years. No difference was detected in the expression of IRS-1, IGF-1, IGF-2, IGFBP3, IR and mTOR between groups with or without T2DM. Conclusion: Our study found higher expression of IGF-1R and IRS-2 proteins in NSCLC patients with preexisting T2DM, and that there was an association with early stage NSCLC, which suggested that IGF signaling may play an important early event in development of NSCLC associated with diabetes. |
Author | Chen, Xin Luo, Wu-Xia Ding, Jing Li, Cong Cheng, Ke Qiu, Meng Chen, Ye Du, Yang Tang, Jie Ge, Jun Liu, Ji-Yan Men, Hai-Tao |
Author_xml | – sequence: 1 fullname: Ding, Jing – sequence: 2 fullname: Tang, Jie – sequence: 3 fullname: Chen, Xin – sequence: 4 fullname: Men, Hai-Tao – sequence: 5 fullname: Luo, Wu-Xia – sequence: 6 fullname: Du, Yang – sequence: 7 fullname: Ge, Jun – sequence: 8 fullname: Li, Cong – sequence: 9 fullname: Chen, Ye – sequence: 10 fullname: Cheng, Ke – sequence: 11 fullname: Qiu, Meng – sequence: 12 fullname: Liu, Ji-Yan |
BookMark | eNqNjb1Ow0AQhE8oSBjIO2xDacn2ObYpI5PwDy5S0EUXs8GrHHvR7VkxL8Oz4iAegGZmNJpPc64m7BhPVJTlZRGXRfY2UVE6S3Vc6qI6U1MR2iR5XuqkyPNIfS-GvcexdAx1Z7xpA3qSQK2A20LjXUDi3xw6hHuW3hLHlnYIt94dQgfLkXEe5gMJEMOL41g-jbVQ4yhPPX9AbbhFD40JhBwEDjRyjUccjlfjYPW1R8jghswGAwo8jyiFXi7V6dZYwemfX6ir5WJV38W7I7jmd7Hrh_nja5akOpldV6nWZaEr_d_dD2wHXV8 |
ContentType | Journal Article |
DBID | JDI |
DEWEY | 616.994 |
DatabaseName | KoreaScience |
DatabaseTitleList | |
DeliveryMethod | fulltext_linktorsrc |
Discipline | Medicine |
DocumentTitleAlternate | Expression Characteristics of Proteins of the Insulin-like Growth Factor Axis in Non-small Cell Lung Cancer Patients with Preexisting Type 2 Diabetes Mellitus |
EISSN | 2476-762X |
EndPage | 5680 |
ExternalDocumentID | JAKO201305981337638 |
GroupedDBID | --- .UV 23N 2WC 53G 5GY 9ZL ADBBV ALMA_UNASSIGNED_HOLDINGS AOIJS BAWUL BCNDV C1A DIK E3Z EBS EJD F5P FRJ GROUPED_DOAJ GX1 HYE JDI OK1 RPM TR2 W2D WOW |
ID | FETCH-kisti_ndsl_JAKO2013059813376383 |
ISSN | 1513-7368 |
IngestDate | Fri Dec 22 12:00:38 EST 2023 |
IsOpenAccess | true |
IsPeerReviewed | true |
IsScholarly | true |
Issue | 10 |
Keywords | insulin early event diabetes mellitus small cell lung cancer insulin receptor Non like growth factor |
Language | Korean |
LinkModel | OpenURL |
MergedId | FETCHMERGED-kisti_ndsl_JAKO2013059813376383 |
Notes | KISTI1.1003/JNL.JAKO201305981337638 |
OpenAccessLink | http://click.ndsl.kr/servlet/LinkingDetailView?cn=JAKO201305981337638&dbt=JAKO&org_code=O481&site_code=SS1481&service_code=01 |
ParticipantIDs | kisti_ndsl_JAKO201305981337638 |
PublicationCentury | 2000 |
PublicationDate | 2013 |
PublicationDateYYYYMMDD | 2013-01-01 |
PublicationDate_xml | – year: 2013 text: 2013 |
PublicationDecade | 2010 |
PublicationTitle | Asian Pacific journal of cancer prevention : APJCP |
PublicationTitleAlternate | Asian Pacific journal of cancer prevention : APJCP |
PublicationYear | 2013 |
SSID | ssib044730644 ssib007832521 ssj0045875 |
Score | 3.9688632 |
Snippet | Background: Preexisting type 2 diabetes mellitus (T2DM) affects the prognosis and mortality of patients with some cancers. Insulin like growth factor (IGF) and... |
SourceID | kisti |
SourceType | Open Access Repository |
StartPage | 5675 |
Title | Expression Characteristics of Proteins of the Insulin-like Growth Factor Axis in Non-small Cell Lung Cancer Patients with Preexisting Type 2 Diabetes Mellitus |
URI | http://click.ndsl.kr/servlet/LinkingDetailView?cn=JAKO201305981337638&dbt=JAKO&org_code=O481&site_code=SS1481&service_code=01 |
Volume | 14 |
hasFullText | 1 |
inHoldings | 1 |
isFullTextHit | |
isPrint | |
link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnZ1La8JAEMcX6aH0UvqkT5lDe5IVjZuHR_GB2Np6sOBNjI00tE2KRir9MD33Y3ZmNxtXKX1dQlhkMZkfs7OTmf8ydmE7rh94Y5ePS7bHhT_yedVz8IJLEzpD36rIRtrujdO-E52BPcjlPoyqpXniF8dvX_aV_MeqOIZ2pS7ZP1g2mxQH8B7ti1e0MF5_ZePmIi1jjeRnc1N4mUrbSIIhVGVuqkZSlp3zp_AxoJzTa_JQaMnjdgq1RSjrYm_iiM-e6Wt1nXJ613MqCiAupqTlHy674XrTgDQ0Zc10X2VxGzqL2yWNzyRNKGiBW9mrmVYAmnIVYzX7S6okRSxSqrLXqWeNZ4302JWOXmVlokGPZWDW0z6TQZjx3lUj7VHI-6PYTHCozlTtjcsV7lbUuTvFQI5ZwnU4evDBigsXJqolwyEji7axuNuOOjdqVXh7bUHMyhQ7tatb-kcYgnq4l0dXTF3lpEdk7N3JcbnoF404SAiXNnZChwTC9qTic_Y8uBOi7UFohDL9Hbad7kGgpoDaZbnHeI9tdtMqi332vuQK1riCeAKaK7pHrsDkChRXoLgC4grCCDKugLgC4goUV6C5AuIKDK6AuAILNFeguTpgl61mv97m8uGG0f3safjFO6wcso0ojoIjBmUxCTxrMqmSyhJG8yMn8NB74AsUbhUj7WOW_36uk59-cMq2LHmCCWXNzthGMp0H5xhHJn5e2vATj2B3lg |
link.rule.ids | 230,315,786,790,891,4043 |
linkProvider | Directory of Open Access Journals |
openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Expression+Characteristics+of+Proteins+of+the+Insulin-like+Growth+Factor+Axis+in+Non-small+Cell+Lung+Cancer+Patients+with+Preexisting+Type+2+Diabetes+Mellitus&rft.jtitle=Asian+Pacific+journal+of+cancer+prevention+%3A+APJCP&rft.au=Ding%2C+Jing&rft.au=Tang%2C+Jie&rft.au=Chen%2C+Xin&rft.au=Men%2C+Hai-Tao&rft.date=2013&rft.issn=1513-7368&rft.eissn=2476-762X&rft.volume=14&rft.issue=10&rft.spage=5675&rft.epage=5680&rft.externalDBID=n%2Fa&rft.externalDocID=JAKO201305981337638 |
thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=1513-7368&client=summon |
thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=1513-7368&client=summon |
thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=1513-7368&client=summon |