The Neuroprotective Effect of Treatment of Valproic Acid in Acute Spinal Cord Injury
Objective: Valproic acid (VPA), as known as histone deacetylase inhibitor, has neuroprotective effects. This study investigated the histological changes and functional recovery from spinal cord injury (SCI) associated with VPA treatment in a rat model. Methods: Locomotor function was assessed accord...
Saved in:
Published in | Journal of Korean Neurosurgical Society Vol. 51; no. 4; pp. 191 - 198 |
---|---|
Main Authors | , , , , , |
Format | Journal Article |
Language | Korean |
Published |
2012
|
Subjects | |
Online Access | Get full text |
Cover
Loading…
Abstract | Objective: Valproic acid (VPA), as known as histone deacetylase inhibitor, has neuroprotective effects. This study investigated the histological changes and functional recovery from spinal cord injury (SCI) associated with VPA treatment in a rat model. Methods: Locomotor function was assessed according to the Basso-Beatlie-Bresnahan scale for 2 weeks in rats after receiving twice daily intraperitoneal injections of 200 mg/kg VPA or the equivalent volume of normal saline for 7 days following SCI. The injured spinal cord was then examined histologically, including quantification of cavitation. Results: Basso-Beatlie-Bresnahan scale scores in rats receiving VPA were significantly higher than in the saline group (p<0.05). The cavity volume in the VPA group was Significantly reduced compared with the control (saline-injected) group (p<0.05). The level of histone acetylation recovered in the VPA group, while it was significantly decreased in the control rats (p<0.05). The macrophage level was significantly decreased in the VPA group (p<0.05). Conclusion: VPA influences the restoration of hyperacetylation and reduction of the inflammatory reaction resulting from SCI, and is effective for histology and motor function recovery. |
---|---|
AbstractList | Objective: Valproic acid (VPA), as known as histone deacetylase inhibitor, has neuroprotective effects. This study investigated the histological changes and functional recovery from spinal cord injury (SCI) associated with VPA treatment in a rat model. Methods: Locomotor function was assessed according to the Basso-Beatlie-Bresnahan scale for 2 weeks in rats after receiving twice daily intraperitoneal injections of 200 mg/kg VPA or the equivalent volume of normal saline for 7 days following SCI. The injured spinal cord was then examined histologically, including quantification of cavitation. Results: Basso-Beatlie-Bresnahan scale scores in rats receiving VPA were significantly higher than in the saline group (p<0.05). The cavity volume in the VPA group was Significantly reduced compared with the control (saline-injected) group (p<0.05). The level of histone acetylation recovered in the VPA group, while it was significantly decreased in the control rats (p<0.05). The macrophage level was significantly decreased in the VPA group (p<0.05). Conclusion: VPA influences the restoration of hyperacetylation and reduction of the inflammatory reaction resulting from SCI, and is effective for histology and motor function recovery. |
Author | Yu, Song-Hee Cho, Dae-Chul Nam, Kyung-Hun Cho, Hee-Jung Sung, Joo-Kyung Kim, Kyoung-Tae |
Author_xml | – sequence: 1 fullname: Yu, Song-Hee – sequence: 2 fullname: Cho, Dae-Chul – sequence: 3 fullname: Kim, Kyoung-Tae – sequence: 4 fullname: Nam, Kyung-Hun – sequence: 5 fullname: Cho, Hee-Jung – sequence: 6 fullname: Sung, Joo-Kyung |
BookMark | eNqNit0KgjAYQEcUZD_v8N10KWyzqV2KGP1AXSTdhuknrWyTbQa9fRI9QFfnHDgTMlRa4YB4TKxiP4qjcEg8Tqnwg4ixMZlbK6-UxoJyJkKP5PkN4YCd0a3RDksnXwhZXfcGuobcYOGeqL5xLpp-kiUkpaxAqp6dQzi1UhUNpNpUsFX3zrxnZFQXjcX5j1OyWGd5uvEf0jp5UZVtLrtkf-SUcc5DEYiQR2IZ_Pt9AP2bQY4 |
ContentType | Journal Article |
DBID | JDI |
DEWEY | 616.8 |
DatabaseName | KoreaScience |
DatabaseTitleList | |
DeliveryMethod | fulltext_linktorsrc |
Discipline | Medicine |
DocumentTitleAlternate | The Neuroprotective Effect of Treatment of Valproic Acid in Acute Spinal Cord Injury |
EISSN | 1598-7876 |
EndPage | 198 |
ExternalDocumentID | JAKO201222653562754 |
GroupedDBID | --- .UV 29K 2WC 5-W 53G 5GY 8JR 8XY 9ZL ABDBF AENEX ALMA_UNASSIGNED_HOLDINGS CS3 D-I DIK E3Z EBD EF. F5P FRP GROUPED_DOAJ HYE JDI KVFHK OK1 RPM W2D |
ID | FETCH-kisti_ndsl_JAKO2012226535627543 |
ISSN | 2005-3711 |
IngestDate | Fri Dec 22 12:03:39 EST 2023 |
IsOpenAccess | true |
IsPeerReviewed | true |
IsScholarly | true |
Issue | 4 |
Keywords | Clip compression model HOAC inhibitor Acetylation Valproic acid Spinal cord injury |
Language | Korean |
LinkModel | OpenURL |
MergedId | FETCHMERGED-kisti_ndsl_JAKO2012226535627543 |
Notes | KISTI1.1003/JNL.JAKO201222653562754 |
OpenAccessLink | http://click.ndsl.kr/servlet/LinkingDetailView?cn=JAKO201222653562754&dbt=JAKO&org_code=O481&site_code=SS1481&service_code=01 |
ParticipantIDs | kisti_ndsl_JAKO201222653562754 |
PublicationCentury | 2000 |
PublicationDate | 2012 |
PublicationDateYYYYMMDD | 2012-01-01 |
PublicationDate_xml | – year: 2012 text: 2012 |
PublicationDecade | 2010 |
PublicationTitle | Journal of Korean Neurosurgical Society |
PublicationTitleAlternate | 대한신경외과학회지 |
PublicationYear | 2012 |
SSID | ssib008502156 ssib053376768 ssib038074812 ssib050733766 ssj0063085 |
Score | 3.7552097 |
Snippet | Objective: Valproic acid (VPA), as known as histone deacetylase inhibitor, has neuroprotective effects. This study investigated the histological changes and... |
SourceID | kisti |
SourceType | Open Access Repository |
StartPage | 191 |
Title | The Neuroprotective Effect of Treatment of Valproic Acid in Acute Spinal Cord Injury |
URI | http://click.ndsl.kr/servlet/LinkingDetailView?cn=JAKO201222653562754&dbt=JAKO&org_code=O481&site_code=SS1481&service_code=01 |
Volume | 51 |
hasFullText | 1 |
inHoldings | 1 |
isFullTextHit | |
isPrint | |
link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1LT8JAEN4YD8aL8RmfZA96MjUtfcGRNJgKAQ9Ww42021aqpDVAD3rwtzuzuyyFEF-XDbtsSmE-Zr9OZr4h5DJKU3CIYaxZdR0GV7e1yDJCjVmxbjNg0G6EtcO9vuM_Wp2BPVjk6fLqkll0wz7W1pX8x6qwBnbFKtk_WFZdFBbgNdgXRrAwjL-2MVfXkGoLmAUk5YiBAwYqhxwmT-EYNmXsusWymAc5GGYIPLzxrlgeFg3e5S_lcoF0ha12iwnG7PmnTcuJ8Jcy5VN5jpLHUov8WfMTBRhvVIjk-UTzRos0RNnGufuO7kYLQrW_H8o3cN0v82pcwqgEKbm6qelKJ5pIx4q6pQ3R62XueaXUbFYNK3A3ajSNyolsiD7Vy2LZK4eYSi3stLr3eDtAK23TRg1mFItFDSHM6_xsK2fTsJHuKC6GwvtWRbvMxm6W7oLr2jjjz2bimHdMnfd7VV8Wnm6Q8mcVehLskh1pKdoSINkjG6_FPtnqycyJAxIAVugKVqjACi1SqrCCkzlWKGKFZjnlWKECKxSxQgVWDsnVbTvwfI3f0jCPp-Phml_GPCKbeZEnx4TGlpumppkYQFCs0Kk3debCHzZNnHrMmM5OSO37a53-tOGMbOOKiF-dk83ZpEwugNHNohq3zBeg50o9 |
link.rule.ids | 230,315,786,790,891,4043 |
linkProvider | ISSN International Centre |
openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=The+Neuroprotective+Effect+of+Treatment+of+Valproic+Acid+in+Acute+Spinal+Cord+Injury&rft.jtitle=Journal+of+Korean+Neurosurgical+Society&rft.au=Yu%2C+Song-Hee&rft.au=Cho%2C+Dae-Chul&rft.au=Kim%2C+Kyoung-Tae&rft.au=Nam%2C+Kyung-Hun&rft.date=2012&rft.issn=2005-3711&rft.eissn=1598-7876&rft.volume=51&rft.issue=4&rft.spage=191&rft.epage=198&rft.externalDBID=n%2Fa&rft.externalDocID=JAKO201222653562754 |
thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=2005-3711&client=summon |
thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=2005-3711&client=summon |
thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=2005-3711&client=summon |