Bidirectional Regulation of Manganese Superoxide Dismutase (MnSOD) on the Radiosensitivity of Esophageal Cancer Cells

• Published in: Asian Pacific journal of cancer prevention : APJCP Vol. 13; no. 7; pp. 3015 - 3023
• Main Authors: Sun, Guo-Gui, Hu, Wan-Ning, Wang, Ya-Di, Yang, Cong-Rong, Lu, Yi-Fang
• Format: Journal Article
• Language: Korean
• Published: 2012
• Subjects: nitric oxide; reactive oxygen species; esophageal carcinoma; Manganese superoxide dismutase

The mitochondrial antioxidant protein manganese superoxide dismutase (MnSOD) may represent a new type of tumor suppressor protein. Overexpression of the cDNA of this gene by plasmid or recombinant lentiviral transfection in various types of cancer leads to growth suppression both in vitro and in viv...