Absence of P53 Gene Mutations in Exons 5 - 7 Among Breast Cancer Patients of Bengalee Hindu Caste Females, West Bengal, India
Background: The high incidence and relatively good prognosis of breast cancer has made it the most prevalent cancer in the world today. A large number of distinct mutations and polymorphisms in the p53 gene have been reported worldwide, but there is no report regarding the role of this inherited sus...
Saved in:
Published in | Asian Pacific journal of cancer prevention : APJCP Vol. 13; no. 9; pp. 4477 - 4479 |
---|---|
Main Authors | , , , , |
Format | Journal Article |
Language | Korean |
Published |
2012
|
Subjects | |
Online Access | Get full text |
Cover
Loading…
Abstract | Background: The high incidence and relatively good prognosis of breast cancer has made it the most prevalent cancer in the world today. A large number of distinct mutations and polymorphisms in the p53 gene have been reported worldwide, but there is no report regarding the role of this inherited susceptibility gene in breast cancer risk among the Bengalee Hindu Caste females of West Bengal, India. Aim of the Study: We investigated the distribution and the nature of p53 gene mutations and polymorphisms in exons 5-7 in a cohort of 110 Bengalee Hindu breast cancer patients and 127 age, sex and caste matched controls by direct sequencing. Results: We did not observe any mutations and polymorphisms in our studied individuals. Conclusion: We therefore conclude that mutations in exons 5-7 of p53 gene are rare causes of breast cancer among Bengalee Hindu caste females, and therefore of little help for genetic counseling and diagnostic purposes. |
---|---|
AbstractList | Background: The high incidence and relatively good prognosis of breast cancer has made it the most prevalent cancer in the world today. A large number of distinct mutations and polymorphisms in the p53 gene have been reported worldwide, but there is no report regarding the role of this inherited susceptibility gene in breast cancer risk among the Bengalee Hindu Caste females of West Bengal, India. Aim of the Study: We investigated the distribution and the nature of p53 gene mutations and polymorphisms in exons 5-7 in a cohort of 110 Bengalee Hindu breast cancer patients and 127 age, sex and caste matched controls by direct sequencing. Results: We did not observe any mutations and polymorphisms in our studied individuals. Conclusion: We therefore conclude that mutations in exons 5-7 of p53 gene are rare causes of breast cancer among Bengalee Hindu caste females, and therefore of little help for genetic counseling and diagnostic purposes. |
Author | Roy, Abhishikta Ghosh Rao, V.R Sarkar, B.N Roy, Rakesh Bandyopadhyay, A.R |
Author_xml | – sequence: 1 fullname: Roy, Abhishikta Ghosh – sequence: 2 fullname: Sarkar, B.N – sequence: 3 fullname: Roy, Rakesh – sequence: 4 fullname: Rao, V.R – sequence: 5 fullname: Bandyopadhyay, A.R |
BookMark | eNqNjM1qAkEQhIdgIBvjO_QlNxdm52fHHFfRqCG4h0BykzHbypC1F-wRcvHdHdEH8FJVFF_Vs-hRR_ggMmVcmbtS_fREVthC506XoycxYA4baYzTsjQmE6dqw0i_CN0WaqvhHQnh8xh9DB0xBILp_yVYyMFBte9oB-MDeo4w8Wl3gDqhSJEvD2OknW8RYR6oOSaCI8IM96njIXxjWl2RISyoCf5FPG59yzi4eV-8zqZfk3n-FziGNTXcrpfVx0rJQkn1ZqUZJbX6Xu4MWCJNnQ |
ContentType | Journal Article |
DBID | JDI |
DEWEY | 616.994 |
DatabaseName | KoreaScience |
DatabaseTitleList | |
DeliveryMethod | fulltext_linktorsrc |
Discipline | Medicine |
DocumentTitleAlternate | Absence of P53 Gene Mutations in Exons 5 - 7 Among Breast Cancer Patients of Bengalee Hindu Caste Females, West Bengal, India |
EISSN | 2476-762X |
EndPage | 4479 |
ExternalDocumentID | JAKO201202950482955 |
GroupedDBID | --- .UV 23N 2WC 53G 5GY 9ZL ADBBV ALMA_UNASSIGNED_HOLDINGS AOIJS BAWUL BCNDV C1A DIK E3Z EBS EJD F5P FRJ GROUPED_DOAJ GX1 HYE JDI OK1 RPM TR2 W2D WOW |
ID | FETCH-kisti_ndsl_JAKO2012029504829553 |
ISSN | 1513-7368 |
IngestDate | Fri Dec 22 12:03:56 EST 2023 |
IsOpenAccess | true |
IsPeerReviewed | true |
IsScholarly | true |
Issue | 9 |
Keywords | Bengalee Hindu caste females breast cancer exons 5, 6 and 7 p53 India |
Language | Korean |
LinkModel | OpenURL |
MergedId | FETCHMERGED-kisti_ndsl_JAKO2012029504829553 |
Notes | KISTI1.1003/JNL.JAKO201202950482955 |
OpenAccessLink | http://click.ndsl.kr/servlet/LinkingDetailView?cn=JAKO201202950482955&dbt=JAKO&org_code=O481&site_code=SS1481&service_code=01 |
ParticipantIDs | kisti_ndsl_JAKO201202950482955 |
PublicationCentury | 2000 |
PublicationDate | 2012 |
PublicationDateYYYYMMDD | 2012-01-01 |
PublicationDate_xml | – year: 2012 text: 2012 |
PublicationDecade | 2010 |
PublicationTitle | Asian Pacific journal of cancer prevention : APJCP |
PublicationTitleAlternate | Asian Pacific journal of cancer prevention : APJCP |
PublicationYear | 2012 |
SSID | ssib044730644 ssib007832521 ssj0045875 |
Score | 3.8911614 |
Snippet | Background: The high incidence and relatively good prognosis of breast cancer has made it the most prevalent cancer in the world today. A large number of... |
SourceID | kisti |
SourceType | Open Access Repository |
StartPage | 4477 |
Title | Absence of P53 Gene Mutations in Exons 5 - 7 Among Breast Cancer Patients of Bengalee Hindu Caste Females, West Bengal, India |
URI | http://click.ndsl.kr/servlet/LinkingDetailView?cn=JAKO201202950482955&dbt=JAKO&org_code=O481&site_code=SS1481&service_code=01 |
Volume | 13 |
hasFullText | 1 |
inHoldings | 1 |
isFullTextHit | |
isPrint | |
link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1LT9tAEF5FHFAvFY-iPgDNgZ7MRnW8juOjEwFRqtAq0Co3tLY3Igp1UOJICImfwf9lZnftbBHqg8vKXk12nczneWV2hrGjwE_9TtTJeZCmIRdZR3AZC59PZJq12rkI5YTiHcPzdv-HGIzDcaPx6GQtrcq0md2_eK7kNVzFOeQrnZL9D87Wi-IEXiN_cUQO4_hPPE7SpX4xKY8tDHQJaW-4Ktf54Sd3dBF63Iu8RLcV6lISeun1iNkLKtA_VTYRpqsK0hbK66ObvkIK5L93qn5J2xWbetBYIiNY8ql0TdtEH8e0SX5uRYrM7HVri0UR3Cga-X3Qq8-WjUxEMEmvKSQ2K6V3dj1f1pHqC7mYmUTwbvP82WdGcqbWlCOpQ78_myM3nOG3XNnrBzwKTJedptJzLRG1Ocrr8W8CO3CAGTvSVwjbEkZVt_FazVV_7T_TfnVO4iD5-o0e6EsrDlGs4UilC6j4kOOok5SKUAg6Rg_uQl6cqPS_CDu6vHP9ddDtIV9g6tgtl1vsrXU4IDHo2WaN2XyHbQ5tSsUue7AggvkEEERAIIIaRDAtQIMIQuAQgQYRGBCBARFUIKIVKhCBBhFoEIEF0TEQhCzJMWgAvWOfT08ue32un_2qyJc3Vy_8RMEe2yjmhXrPQOWoHKT04wy9XDQBYjQHsyifSPQgyO79wA7_vNbHvxF8Ym9oxkTA9tlGuVipA7QJy_RQs-gJE6ReQw |
link.rule.ids | 230,315,786,790,891,4043 |
linkProvider | Directory of Open Access Journals |
openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Absence+of+P53+Gene+Mutations+in+Exons+5+-+7+Among+Breast+Cancer+Patients+of+Bengalee+Hindu+Caste+Females%2C+West+Bengal%2C+India&rft.jtitle=Asian+Pacific+journal+of+cancer+prevention+%3A+APJCP&rft.au=Roy%2C+Abhishikta+Ghosh&rft.au=Sarkar%2C+B.N&rft.au=Roy%2C+Rakesh&rft.au=Rao%2C+V.R&rft.date=2012&rft.issn=1513-7368&rft.eissn=2476-762X&rft.volume=13&rft.issue=9&rft.spage=4477&rft.epage=4479&rft.externalDBID=n%2Fa&rft.externalDocID=JAKO201202950482955 |
thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=1513-7368&client=summon |
thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=1513-7368&client=summon |
thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=1513-7368&client=summon |