Mycobacterium tuberculosis-Induced Expression of Leukotactin-1 Is Mediated by the PI3-K/PDK1/Akt Signaling Pathway

• Published in: Molecules and cells Vol. 29; no. 1; pp. 35 - 39
• Main Authors: Cho, Jang-Eun, Kim, Yoon-Suk, Park, Sang-Jung, Cho, Sang-Nae, Lee, Hye-Young
• Format: Journal Article
• Language: Korean
• Published: 2010
• Subjects: 3-phosphoinositide-dependent kinase 1; Mycobacterium tuberculosis; Akt; Leukotactin-1; phosphatidylinositol 3-kinase

Chemokines function in the migration of circulating leukocytes to regions of inflammation, and have been implicated in chronic inflammatory conditions including myco-bacterial infection. We investigated whether Leukotactin-1 (Lkn-1), a novel member of the CC-chemokines, is involved in the immune res...