Lipid Lowering and Antioxidant Effects of Newly Synthesized 4-[(Butylsulfinyl)methyl]-1,2-benzenediol (SMBD) in Diet-induced Hypercholesterolemic Rabbits

• Published in: Bulletin of the Korean Chemical Society Vol. 31; no. 11; pp. 3327 - 3332
• Main Authors: Kim, Hyun-Ju, Noh, Jeong-Sook, Kwon, Myung-Ja, Song, Su-Hee, Suh, Hong-Suk, Kim, Mi-Jeong, Song, Yeong-Ok
• Format: Journal Article
• Language: Korean
• Published: 2010
• Subjects: Oxidative stress; Hypercholesterolemia; 4-[(Butylsulfinyl)methyl]-1,2-benzenediol (SMBD); Aorta; Antioxidant

We investigated the effects of newly synthesized 4-[(butylsulfinyl)methyl]-1,2-benzenediol (SMBD) on the prevention of atherosclerosis in hypercholesterolemic rabbits. SMBD exhibited stronger inhibition of $Cu^{2+}$-induced low-density lipoprotein oxidation than that of ascorbic acid or simvastatin....