Additive Effects of Heat and p38 MAPK Inhibitor Treatment on Melanin Synthesis

• Published in: Archives of pharmacal research Vol. 30; no. 5; pp. 581 - 586
• Main Authors: Kim, Dong-Seok, Park, Seo-Hyoung, Kwon, Sun-Bang, Na, Jung-Im, Huh, Chang-Hun, Park, Kyoung-Chan
• Format: Journal Article
• Language: Korean
• Published: 2007
• Subjects: Heat; Melanogenesis; p38 MAPK; Tyrosinase; ERK

It has been reported that the activation of extracellular signal-regulated kinase (ERK) reduces melanin synthesis. Recently, we also found that heat treatment induces ERK activation and inhibits melanogenesis in Mel-Ab cells (a mouse melanocyte cell line). In addition, it was reported that p38 MAPK...