Effects of opioid and non-opioid antagonists, pH and enzymes on Corchorus olitorius antinociception in mice
The present study was carried out to determine the involvement of opioid and non-opioid receptor and the effect of pH and enzymes on the recently reported antinociceptive activity of aqueous extract of Corchorus olitorius (AECO) leaves using the abdominal constriction test. The extract was prepared...
Saved in:
Published in | Oriental pharmacy and experimental medicine Vol. 6; no. 3; pp. 186 - 195 |
---|---|
Main Authors | , , , , |
Format | Journal Article |
Language | Korean |
Published |
2006
|
Subjects | |
Online Access | Get full text |
Cover
Loading…
Abstract | The present study was carried out to determine the involvement of opioid and non-opioid receptor and the effect of pH and enzymes on the recently reported antinociceptive activity of aqueous extract of Corchorus olitorius (AECO) leaves using the abdominal constriction test. The extract was prepared by soaking the dried powdered leaves of Corchorus (C.) olitorius in distilled water overnight, and the supernatant obtained was considered as a stock solution with 100% concentration/ strength. The extract, administered subcutaneously in the concentrations/ strength of 10, 50 and 100%, was found to show a significant concentration-independent antinociception. The 50% concentration AECO were further used to study on the above mentioned parameters. The extract exhibited: significant (P < 0.05) decreased in activity when pre-treated (s.c.) against 10 mg/kg naloxonazine, bicuculine (10 mg/kg), phenoxybenzamine (10 mg/kg), 10 mg/kg pindolol, and 5 mg/kg mecamylamme, but not 10 mg/kg naltrindole, 10 mg/kg atropine, respectively; significant (P < 0.05) decreased in activity after pre-treatment against 10% a-amylase, but not 1 % protease or 10% lipase and; significant (P < 0.05) decreased in activity after exposure to alkaline condition (pH between 9 and 13) while maintaining the activity at acidic condition, respectively. The C. olitorius leaves antinociception, which involved, at least in part, activation of $\mu-opioid,\;\alpha-and\;\beta-adrenergic$, and nicotinic receptors, was found to decrease under alkaline condition and in the presence of $\alpha-amylase$. |
---|---|
AbstractList | The present study was carried out to determine the involvement of opioid and non-opioid receptor and the effect of pH and enzymes on the recently reported antinociceptive activity of aqueous extract of Corchorus olitorius (AECO) leaves using the abdominal constriction test. The extract was prepared by soaking the dried powdered leaves of Corchorus (C.) olitorius in distilled water overnight, and the supernatant obtained was considered as a stock solution with 100% concentration/ strength. The extract, administered subcutaneously in the concentrations/ strength of 10, 50 and 100%, was found to show a significant concentration-independent antinociception. The 50% concentration AECO were further used to study on the above mentioned parameters. The extract exhibited: significant (P < 0.05) decreased in activity when pre-treated (s.c.) against 10 mg/kg naloxonazine, bicuculine (10 mg/kg), phenoxybenzamine (10 mg/kg), 10 mg/kg pindolol, and 5 mg/kg mecamylamme, but not 10 mg/kg naltrindole, 10 mg/kg atropine, respectively; significant (P < 0.05) decreased in activity after pre-treatment against 10% a-amylase, but not 1 % protease or 10% lipase and; significant (P < 0.05) decreased in activity after exposure to alkaline condition (pH between 9 and 13) while maintaining the activity at acidic condition, respectively. The C. olitorius leaves antinociception, which involved, at least in part, activation of $\mu-opioid,\;\alpha-and\;\beta-adrenergic$, and nicotinic receptors, was found to decrease under alkaline condition and in the presence of $\alpha-amylase$. |
Author | Sulaiman MR Fatimah CA Zakaria Zainul Amiruddin Pubalan S Neelendran M |
Author_xml | – sequence: 1 fullname: Zakaria Zainul Amiruddin – sequence: 2 fullname: Neelendran M – sequence: 3 fullname: Pubalan S – sequence: 4 fullname: Sulaiman MR – sequence: 5 fullname: Fatimah CA |
BookMark | eNqNjDsLwjAUhYNUsD7-QxY3C0mKoR2lVIoOLu5S21Qvbe8tTRz01xtEnJ3O-TiPOQuQ0ExYqJSUkRQ6DVgot2kSqTjRM7ayFq5CSa2E0knI2rxpTOUsp4bTAAQ1L7Hm_iT6oStvhGCd3fCh-MQGX8_e-BHyjMbqTuPDQweORvDOTwCpgsoMDnwHkPcelmzalJ01q68u2Hqfn7Miav05XLC23eWwO56UEFrIVKaJ1ioW8b-9N60XSy0 |
ContentType | Journal Article |
DBID | JDI |
DEWEY | 615.5 |
DatabaseName | KoreaScience (Open Access) |
DatabaseTitleList | |
DeliveryMethod | fulltext_linktorsrc |
Discipline | Medicine Pharmacy, Therapeutics, & Pharmacology |
DocumentTitleAlternate | Effects of opioid and non-opioid antagonists, pH and enzymes on Corchorus olitorius antinociception in mice |
EISSN | 2211-1069 |
EndPage | 195 |
ExternalDocumentID | JAKO200601919866230 |
GroupedDBID | --- -EM .UV 06D 0VY 123 203 29~ 2KG 2VQ 30V 4.4 408 67N 96X 9ZL AAAVM AAIAL AAJKR AANXM AARHV AARTL AATVU AAYIU AAYQN AAYTO AAZMS ABFTV ABJNI ABJOX ABKCH ABPLI ABQBU ABTHY ABTMW ABXPI ACGFS ACKNC ACMLO ADBBV ADHHG ADHIR ADINQ ADKPE ADRFC ADURQ ADYFF ADZKW AEBTG AEGNC AEJHL AEJRE AEOHA AEPYU AETCA AEXYK AFWTZ AFZKB AGAYW AGDGC AGJBK AGQMX AGWZB AGYKE AHAVH AHBYD AHKAY AHSBF AHYZX AIIXL AITGF AJBLW AJRNO AKMHD ALFXC ALMA_UNASSIGNED_HOLDINGS AMKLP AMYQR ANMIH AXYYD BAWUL BGNMA CS3 CSCUP DIK EBS EIOEI EJD ESBYG FIGPU FINBP FRRFC FSGXE FYJPI GGRSB GJIRD GQ6 GQ7 HF~ HMJXF HRMNR I0C IXD JBSCW JDI KOV KVFHK M4Y NQJWS NU0 O9J P6G R9I RIG RLLFE RSV S1Z S27 S3A S3B SBL SHX SISQX SNE SNX SPISZ SSXJD STPWE T13 TR2 TSG U2A U9L UG4 UZXMN VFIZW W48 ZCN ZOVNA ~A9 |
ID | FETCH-kisti_ndsl_JAKO2006019198662303 |
ISSN | 1598-2386 |
IngestDate | Fri Dec 22 12:00:34 EST 2023 |
IsOpenAccess | true |
IsPeerReviewed | false |
IsScholarly | false |
Issue | 3 |
Keywords | Enzymes Opioid pH Antinociception Non-opioid Corchorus olitorius Abdominal constriction test |
Language | Korean |
LinkModel | OpenURL |
MergedId | FETCHMERGED-kisti_ndsl_JAKO2006019198662303 |
Notes | KISTI1.1003/JNL.JAKO200601919866230 |
OpenAccessLink | http://click.ndsl.kr/servlet/LinkingDetailView?cn=JAKO200601919866230&dbt=JAKO&org_code=O481&site_code=SS1481&service_code=01 |
ParticipantIDs | kisti_ndsl_JAKO200601919866230 |
PublicationCentury | 2000 |
PublicationDate | 2006 |
PublicationDateYYYYMMDD | 2006-01-01 |
PublicationDate_xml | – year: 2006 text: 2006 |
PublicationDecade | 2000 |
PublicationTitle | Oriental pharmacy and experimental medicine |
PublicationTitleAlternate | Oriental pharmacy and experimental medicine |
PublicationYear | 2006 |
SSID | ssib021620268 ssj0067166 ssib033405575 ssib033405574 |
Score | 2.7480183 |
Snippet | The present study was carried out to determine the involvement of opioid and non-opioid receptor and the effect of pH and enzymes on the recently reported... |
SourceID | kisti |
SourceType | Open Access Repository |
StartPage | 186 |
Title | Effects of opioid and non-opioid antagonists, pH and enzymes on Corchorus olitorius antinociception in mice |
URI | http://click.ndsl.kr/servlet/LinkingDetailView?cn=JAKO200601919866230&dbt=JAKO&org_code=O481&site_code=SS1481&service_code=01 |
Volume | 6 |
hasFullText | 1 |
inHoldings | 1 |
isFullTextHit | |
isPrint | |
link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1LT4NAEN4YD8aL8RnfmYN6sZiyIIWjMZqqqRqtifFigIVkU4UGy6H99c4ssNDG-LoQdssj9PsyO7M78y1jB-gROG0_5EZsup5h21bbcIO4Y8Q4toVWzAUPqd65d-t0n-zr59PnerlAVZeMgpNw8mVdyX9QxT7Elapk_4Csfih24Dnii0dEGI-_wviiTsZIhzKVSnb1GAN6Qzdp0YnEcRVcw666IEomY9JoSqngD3meZjk20B9PM5mTZvNIJohZmfBCMyLvZYZc5cbeZWUZ5bBQvi5EnKZ2C5hdtH_xBxiW-8cvvkxypMW7zHIhpObmbUQDoMho8Ujb6zygzMt6evYxf_MlrTr0HqanK5q21UP4rEr5WvVxrjLqit1aKoPsNHhnNYyrWd1atIrNOacltGeGNp1weH12c8eV9oxneq6DPh9N85CyEPnRVzeVCeKmwzEq1SbJsmwSKbNn2jrCcjDcVAVs1bdhjEOOv2w4Kf1ltlRGF3BWUGWFzQ3SVbbQK6FYZUf3JV4t6NeFdx8tOIL7WsN8vMYGJbUgjaHgEiDCUFMLGtRqwbCrfi6JBWkCmligiQUzxAKZABFrnR1eXvTPu4b6pNdEfLy9fvFPWhtsHt8fbTJox24HXfoo9ERko2fqmTyIHNc_NUXYEbbYYvvfP2v7pwt22GI9C7bL5kdZHu2hXzgK9hWSn88pags |
link.rule.ids | 230,315,786,790,891,4043 |
linkProvider | Flying Publisher |
openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Effects+of+opioid+and+non-opioid+antagonists%2C+pH+and+enzymes+on+Corchorus+olitorius+antinociception+in+mice&rft.jtitle=Oriental+pharmacy+and+experimental+medicine&rft.au=Zakaria+Zainul+Amiruddin&rft.au=Neelendran+M&rft.au=Pubalan+S&rft.au=Sulaiman+MR&rft.date=2006&rft.issn=1598-2386&rft.eissn=2211-1069&rft.volume=6&rft.issue=3&rft.spage=186&rft.epage=195&rft.externalDBID=n%2Fa&rft.externalDocID=JAKO200601919866230 |
thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=1598-2386&client=summon |
thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=1598-2386&client=summon |
thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=1598-2386&client=summon |