Hepatoprotective activity of Indigofera aspalathoides extract against CCl 4 -induced liver damage

The plant Indigofera aspalathoides are used by a large number of tribes in India for the treatment of various hepatic disorder. The methanol extract of Indigofera aspalathoides (MEIA) was evaluated for its effect on carbontetrachloride $(CCl_{4})$ induced liver damage. Biochemical parameters such as...

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Published inOriental pharmacy and experimental medicine Vol. 4; no. 2; pp. 100 - 103
Main Authors Gupta, M, Mazumder, U.K, Haldar, P.K, Manikandan, L, Senthilkumar, G.P, Kander, C.C
Format Journal Article
LanguageKorean
Published 2004
Subjects
Indigofera aspalathoides
Hepatoprotective
Silymarin
Carbontetrachloride
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Abstract The plant Indigofera aspalathoides are used by a large number of tribes in India for the treatment of various hepatic disorder. The methanol extract of Indigofera aspalathoides (MEIA) was evaluated for its effect on carbontetrachloride $(CCl_{4})$ induced liver damage. Biochemical parameters such as serum glutamine oxaloacetate trasaminase (SGOT), serum glutamine pyruvate transaminase (SGPT), serum alkaline phosphatase (ALP), total serum protein (TP), thiobarbituric acid reactive substances (TBRS) and glutathione content of the liver were estimated to assess liver function and metabolism. Biochemical observations suggest that methanol extract of Indigofera aspalathoides (MEIA) significantly restored the liver function and metabolism towards normal condition in $CCl_{4}$-induced hepatic damage.
AbstractList The plant Indigofera aspalathoides are used by a large number of tribes in India for the treatment of various hepatic disorder. The methanol extract of Indigofera aspalathoides (MEIA) was evaluated for its effect on carbontetrachloride $(CCl_{4})$ induced liver damage. Biochemical parameters such as serum glutamine oxaloacetate trasaminase (SGOT), serum glutamine pyruvate transaminase (SGPT), serum alkaline phosphatase (ALP), total serum protein (TP), thiobarbituric acid reactive substances (TBRS) and glutathione content of the liver were estimated to assess liver function and metabolism. Biochemical observations suggest that methanol extract of Indigofera aspalathoides (MEIA) significantly restored the liver function and metabolism towards normal condition in $CCl_{4}$-induced hepatic damage.
Author Gupta, M
Kander, C.C
Mazumder, U.K
Manikandan, L
Senthilkumar, G.P
Haldar, P.K
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Keywords Indigofera aspalathoides
Hepatoprotective
Silymarin
Carbontetrachloride
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