Synthesis and $PGE_2$ Inhibitory Activity of Vinylated and Allylated Chrysin Analogues
Vinylated and allylated chrysin analogues were prepared as congeners of prenylated flavonoids and evaluated their anti-inflammatory activity. 8-Substituted chrysin analogues were prepared from 2 -hydroxy-3 -iodo-4 ,6 -dimethoxyacetophenone in 3 steps. 3-Allylated chrysin analogues were prepared from...
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| Published in | Archives of pharmacal research Vol. 26; no. 8; pp. 581 - 584 |
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| Main Authors | , , , , , |
| Format | Journal Article |
| Language | Korean |
| Published |
2003
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| Subjects | |
| Online Access | Get full text |
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| Abstract | Vinylated and allylated chrysin analogues were prepared as congeners of prenylated flavonoids and evaluated their anti-inflammatory activity. 8-Substituted chrysin analogues were prepared from 2 -hydroxy-3 -iodo-4 ,6 -dimethoxyacetophenone in 3 steps. 3-Allylated chrysin analogues were prepared from chrysin in 3 steps. Synthesized chrysin analogues (4, 5 and 8) showed moderate inhibitory activities of $PGE_2$ production from LPS-induced RAW 264.7 cells. |
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| AbstractList | Vinylated and allylated chrysin analogues were prepared as congeners of prenylated flavonoids and evaluated their anti-inflammatory activity. 8-Substituted chrysin analogues were prepared from 2 -hydroxy-3 -iodo-4 ,6 -dimethoxyacetophenone in 3 steps. 3-Allylated chrysin analogues were prepared from chrysin in 3 steps. Synthesized chrysin analogues (4, 5 and 8) showed moderate inhibitory activities of $PGE_2$ production from LPS-induced RAW 264.7 cells. |
| Author | Sin, Kwan-Seog Park, Hae-Il Oh, Jeong-Won Dao, Tran-Thanh Kim, Hyun-Pyo Chi, Yeon-Sook |
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| Keywords | Prenylated flavonoids PGE_2$ production Anti-inflammatory activity Vinylated chrysin analogues Cyclooxygenase-2 Allylated chrysin analogues Stille reaction |
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| Title | Synthesis and $PGE_2$ Inhibitory Activity of Vinylated and Allylated Chrysin Analogues |
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