Synthesis and $PGE_2$ Inhibitory Activity of Vinylated and Allylated Chrysin Analogues

Vinylated and allylated chrysin analogues were prepared as congeners of prenylated flavonoids and evaluated their anti-inflammatory activity. 8-Substituted chrysin analogues were prepared from 2 -hydroxy-3 -iodo-4 ,6 -dimethoxyacetophenone in 3 steps. 3-Allylated chrysin analogues were prepared from...

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Published inArchives of pharmacal research Vol. 26; no. 8; pp. 581 - 584
Main Authors Dao, Tran-Thanh, Oh, Jeong-Won, Chi, Yeon-Sook, Kim, Hyun-Pyo, Sin, Kwan-Seog, Park, Hae-Il
Format Journal Article
LanguageKorean
Published 2003
Subjects
Prenylated flavonoids
PGE_2$ production
Anti-inflammatory activity
Vinylated chrysin analogues
Cyclooxygenase-2
Allylated chrysin analogues
Stille reaction
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Summary:Vinylated and allylated chrysin analogues were prepared as congeners of prenylated flavonoids and evaluated their anti-inflammatory activity. 8-Substituted chrysin analogues were prepared from 2 -hydroxy-3 -iodo-4 ,6 -dimethoxyacetophenone in 3 steps. 3-Allylated chrysin analogues were prepared from chrysin in 3 steps. Synthesized chrysin analogues (4, 5 and 8) showed moderate inhibitory activities of $PGE_2$ production from LPS-induced RAW 264.7 cells.
Bibliography:KISTI1.1003/JNL.JAKO200311922264438
ISSN:0253-6269
1976-3786