재발성 급성 담관염 환자의 담도과오종에서 발생한 간내 담도암: 증례 보고 및 문헌 고찰

• Published in: The Korean journal of gastroenterology Vol. 82; no. 3; pp. 145 - 150
• Main Authors: 이상민, Sang Min Lee, 김기배, Ki Bae Kim, 한정호, Joung-ho Han, 우창곡, Chang Gok Woo, 채희복, Hee Bok Chae, 박선미, Seon Mee Park
• Format: Journal Article
• Language: Korean
• Published: 대한소화기학회 30.09.2023
• Subjects: Biliary hamartoma; Cholangitis; Intrahepatic cholangiocarcinoma
• ISSN: 1598-9992

Biliary hamartomas are tumor-like malformations of the liver. Biliary hamartomas are a type of fibrocystic disorder originating from ductal plate malformation and are typically considered benign, but with the risk of malignant transformation. In this case report, we present a rare occurrence of intrahepatic cholangiocarcinoma (ICC) that developed from biliary hamartomas, along with a literature review. A 76-year-old man with a diagnosis of biliary hamartomas had a history of recurrent cholangitis for 12 years, necessitating cholecystectomy, ERCP, and repeated antibiotic treatments. During his last episode, imaging studies revealed a hypervascular infiltrative mass in the right posterior liver segment. A liver biopsy confirmed adenocarcinoma and subsequent surgical pathology revealed ICC originating from biliary hamartomas. Chronic inflammation in the bile duct associated with biliary hamartomas may serve as a potential trigger for malignant transformation, as observed in this case. Therefore, close surveillance is essential for patients with biliary hamartomas presenting with infectious complications. (Korean J Gastroenterol 2023;82:145-150)